Dora, M., Ahmed, M., Attia, S., Gouda, T. (2022). Efficacy of Marik Protocol in the Treatment of Septic Shock (Hydrocortisone, Ascorbic Acid and Thiamine). test, 89(2), 7497-7503. doi: 10.21608/ejhm.2022.276599
Mohamed El-Morsy Abo-Zaid Dora; Mohamed Elsaid Ahmed; Samir Mohamed Attia; Tarek Elsayed Gouda. "Efficacy of Marik Protocol in the Treatment of Septic Shock (Hydrocortisone, Ascorbic Acid and Thiamine)". test, 89, 2, 2022, 7497-7503. doi: 10.21608/ejhm.2022.276599
Dora, M., Ahmed, M., Attia, S., Gouda, T. (2022). 'Efficacy of Marik Protocol in the Treatment of Septic Shock (Hydrocortisone, Ascorbic Acid and Thiamine)', test, 89(2), pp. 7497-7503. doi: 10.21608/ejhm.2022.276599
Dora, M., Ahmed, M., Attia, S., Gouda, T. Efficacy of Marik Protocol in the Treatment of Septic Shock (Hydrocortisone, Ascorbic Acid and Thiamine). test, 2022; 89(2): 7497-7503. doi: 10.21608/ejhm.2022.276599

Efficacy of Marik Protocol in the Treatment of Septic Shock (Hydrocortisone, Ascorbic Acid and Thiamine)

The Egyptian Journal of Hospital Medicine
Article 207, Volume 89, Issue 2, October 2022, Pages 7497-7503    PDF (345.04 K)
DOI: 10.21608/ejhm.2022.276599
Authors
Mohamed El-Morsy Abo-Zaid Dora* 1; Mohamed Elsaid Ahmed1; Samir Mohamed Attia2; Tarek Elsayed Gouda3
1Departments of 1Critical Care
22Vascular Surgery
33Internal Medicine, Faculty of Medicine, Mansoura University, Egypt
Abstract
Background: Septic shock is a life-threatening state characterized by inability of the organism to maintain sufficient blood pressure and thus end-organ perfusion because of sepsis. The cornerstones of treatment of sepsis and septic shock largely consist of early diagnosis of sepsis, control of infection source, early antimicrobials and supportive treatment with adequate hydration and vasopressor drugs.
Objective: The current study aimed to evaluate the efficacy of Marik protocol treatment for septic shock.
Patients and Methods: This was a prospective study that included 100 patients with septic shock who arrived to Emergency Departments of both Al-Azhar and Al-Mansoura University Hospitals over one year (January 2021-December 2021). Entire subjected were divided into a control group who administered a standard treatment and a treatment group who administered IV vitamin C, thiamine and hydrocortisone within 24 h after intensive care unit (ICU) admission.
Results: Marik group was linked to a significant decrease in hospital mortality 4 (8%) and ICU mortality rate 45 (90%) in comparison with controls (P<0.001). A significant decrease in SOFA score was recorded among Marik group in comparison with control subjects (P<0.05). A statistically reduction in lactate co concentration during follow-up was recorded in Marik group only.
Conclusion: Marik group was linked to a significant reduction in hospital and ICU mortality rate. A significant reduction in SOFA score was recorded among Marik group.  
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