protective and therapeutic effect of omega_3 against nephrotoxicity | ||
| Mansoura Veterinary Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 22 January 2023 | ||
| Document Type: Original Articles | ||
| DOI: 10.21608/mvmj.2023.185092.1128 | ||
| Author | ||
| zahraa magdy farid* | ||
| faculty of veterinary medicine mansoura university , biochemistry department | ||
| Abstract | ||
| Objective: to determine the therapeutic and protective effects of omega 3 on the cisplatin induced renal toxicity in albino rats. Design: Randomized controlled study. Animal: 50 adult male albino rats weighting (200-230 g). Procedures: There was five groups of rats for control, omega 3 ingested, cisplatin injected, cisplatin injected then treated with omega 3 and omega 3 ingested then injected with cisplatin. After 5 weeks of follow up the serum levels of creatinine, uric acid, LDH, LDL, TG, TC, MAD, SOD, CAT and GSH were determined. Results: there was significant (Pvalue<0.001) increase in serum levels of creatinine, uric acid, LDH, LDL, TG, TC and MAD and decrease in levels of SOD, CAT and GSH in the cisplatin injected animals without omega 3 ingestion. However these parameters were improved in the omega 3 treated animals and especially in the protective group that gave values resembling the control groups. Conclusion and clinical relevance: We concluded that omega 3 is a very useful protective and to some extent therapeutic agent against cisplatin induced renal toxicity. | ||
| Keywords | ||
| cisplatin; Omega_3; renal; rats; toxicity | ||
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