Fouad, M., Omar, H., Hassan, W., Hashem, A. (2019). Mupirocin Resistance among Methicillin Resistant Staphylococcus aureus Causing Surgical Site Infections. test, 28(4), 65-71. doi: 10.21608/ejmm.2019.283216
Marwa M. Fouad; Hanan H. Omar; Wafaa H. Hassan; Asmaa A. Hashem. "Mupirocin Resistance among Methicillin Resistant Staphylococcus aureus Causing Surgical Site Infections". test, 28, 4, 2019, 65-71. doi: 10.21608/ejmm.2019.283216
Fouad, M., Omar, H., Hassan, W., Hashem, A. (2019). 'Mupirocin Resistance among Methicillin Resistant Staphylococcus aureus Causing Surgical Site Infections', test, 28(4), pp. 65-71. doi: 10.21608/ejmm.2019.283216
Fouad, M., Omar, H., Hassan, W., Hashem, A. Mupirocin Resistance among Methicillin Resistant Staphylococcus aureus Causing Surgical Site Infections. test, 2019; 28(4): 65-71. doi: 10.21608/ejmm.2019.283216

Mupirocin Resistance among Methicillin Resistant Staphylococcus aureus Causing Surgical Site Infections

Egyptian Journal of Medical Microbiology
Volume 28, Issue 4, October 2019, Pages 65-71    PDF (323.39 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2019.283216
Authors
Marwa M. Fouad* 1; Hanan H. Omar2; Wafaa H. Hassan3; Asmaa A. Hashem1
1Department of Microbiology and Medical Immunology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
2Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
3Infectious and Endemic Diseases Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Abstract
Background: Methicillin Resistant Staphylococcus aureus (MRSA) is a major cause of serious infections. MRSA is a devastating complication, leading to increased mortality rates, increased hospital stay and costs. Topical mupirocin is used to eradicate nasal carriage and treat local infections with MRSA. Emergence of mupirocin resistance seriously adds to the problem of MRSA infections. Objective: This study aimed to determine the prevalence of mupirocin resistance and MupA gene among MRSA isolates causing surgical site infections. Methods: A total of 30 MRSA isolates from 150 patients with surgical site infections were identified. Mupirocin resistance was assessed using the E-test and polymerase chain reaction targeting mupA gene. Biofilm formation was tested. Results: Out of the 30 MRSA strains, 16.7% were mupirocin resistant and 10% were mupirocin resistant and carrying MupA gene. All of these isolates were biofilm producers and generally, the biofilm producers showed more resistance to antibiotics than non producers. Conclusion: MRSA infection along with mupirocin resistance represent a warning sign. Thus, it is advisable to test for MRSA colonization and infection among health care staff to control its spread.
Keywords
Mupirocin resistance; MRSA; surgical site infection
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