Nanoemulsion formulation for enhancing the aqueous solubility and systemic bioavailability of poorly soluble drugs. | ||
| Records of Pharmaceutical and Biomedical Sciences | ||
| Volume 7, Issue 3, January 2023, Pages 103-108 PDF (424.24 K) | ||
| Document Type: Mini-reviews | ||
| DOI: 10.21608/rpbs.2023.203561.1221 | ||
| Authors | ||
| Shadeed Gad* 1; Rasha Zidan2 | ||
| 1Faculty of Pharmacy - Suez Canal University | ||
| 2Dept. of Pharmaceutics & Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, | ||
| Abstract | ||
| Nano emulsions are systems for delivering drugs of poor water-solubility with extensive first-pass metabolism and improving their bioavailability. Different techniques develop nano emulsions. Low-energy methods are more effective and do not require expensive equipment, so they should be used instead of high-energy methods. However, high-energy procedures are better for food-substance emulsions as they require a lower surfactant concentration than low-energy approaches. Particularly for low-energy processes, the formulation of nano emulsions involves overlapping techniques. Due to their small particle sizes, nano emulsions are effective in emulsifying active lipophilic compounds and have a variety of uses, which is a promising advantage over conventional emulsions. These systems appear optically clear and have better stability as a result. Also, the diffusion of bioactive substances into the intradermal layers is improved by nano emulsion food component systems, which is crucial in the development of herbal cosmetics. The nano emulsion technology has demonstrated the ability to effectively distribute lipophilic compounds via various administration routes. Nano emulsion systems are beneficial for aesthetic applications due to their transparency, low viscosity, and nano-sized droplets. Antibiotics, anticancer agents, disinfectants, and antiseptics can all be given utilising nano emulsion systems due to their adaptable physiochemical properties, which also enhance the bioactivity of the encapsulated components. | ||
| Keywords | ||
| drug delivery systems; nano emulsion; high-energy approach; low-energy method | ||
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