Khamis, D., Abdel Wahab, A., Omar, H., Mohammed, Z. (2023). Association between Urinary Cyclophilin A and Diabetic Nephropathy in Children with Type 1 Diabetes Mellitus. test, 26(2), 25-34. doi: 10.21608/scumj.2023.300569
Dina F. Khamis; Amina M. Abdel Wahab; Hanan H. Omar; Zeinab A. Mohammed. "Association between Urinary Cyclophilin A and Diabetic Nephropathy in Children with Type 1 Diabetes Mellitus". test, 26, 2, 2023, 25-34. doi: 10.21608/scumj.2023.300569
Khamis, D., Abdel Wahab, A., Omar, H., Mohammed, Z. (2023). 'Association between Urinary Cyclophilin A and Diabetic Nephropathy in Children with Type 1 Diabetes Mellitus', test, 26(2), pp. 25-34. doi: 10.21608/scumj.2023.300569
Khamis, D., Abdel Wahab, A., Omar, H., Mohammed, Z. Association between Urinary Cyclophilin A and Diabetic Nephropathy in Children with Type 1 Diabetes Mellitus. test, 2023; 26(2): 25-34. doi: 10.21608/scumj.2023.300569

Association between Urinary Cyclophilin A and Diabetic Nephropathy in Children with Type 1 Diabetes Mellitus

Suez Canal University Medical Journal
Article 4, Volume 26, Issue 2, February 2023, Pages 25-34    PDF (335.54 K)
Document Type: Original Article
DOI: 10.21608/scumj.2023.300569
Authors
Dina F. Khamis* 1; Amina M. Abdel Wahab2; Hanan H. Omar3; Zeinab A. Mohammed2
1Neonatology Unit, MetGhamr Central Hospital, Egypt
2Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt
3Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background: Diabetes is a group of metabolic diseases marked by hyperglycemia caused by insulin secretion, action, or both. Diabetes chronic hyperglycemia is associated with long-term damage, dysfunction, & failure of numerous organs, most notably eyes, kidneys, nerves, heart, & blood vessels. Aim and objectives: This research aimed to evaluate the association between Urinary Cyclophilin A & diabetic nephropathy in children& adolescents with Type 1 Diabetes Mellitus (T1DM). Subjects and Methods: Sixty children& adolescents were recruited consecutively from those attending diabetes outstudied case clinic in Suez Canal University Children’s Hospital. Thirty years old & gender-matched children & adolescents were recruited as the control group. Results: Concerning urinary CyPA, we found that those with microalbuminuria had the highest urinary CyPA levels when compared to others. This was statistically significant (p < 0.001). On performing post hoc analysis, we found that variation could be explained by the difference among group B included normoalbuminuric diabetic children and adolescents and group C included healthy children and adolescents (p < 0.001), among group A included microalbuminuric diabetic children and adolescents &group C (p < 0.001). Conclusion: Urinary CyPA can be used as an early indicator for Diabetic nephropathy because important great levels of urinary CyPA were detected in T1DM studied cases with DN before the presence of albuminuria.
 
Keywords
Diabetes; juvenile; Cyclophyllin A; relationship
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