Heeba, G., Abolnaga, M., Othman, E. (2023). RECENT APPROACHES FOR SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITORS IN THE MANAGEMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE. test, 46(1), 579-595. doi: 10.21608/bfsa.2023.301257
Gehan H. Heeba; Mohamed Y. Abolnaga; Eman M. Othman. "RECENT APPROACHES FOR SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITORS IN THE MANAGEMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE". test, 46, 1, 2023, 579-595. doi: 10.21608/bfsa.2023.301257
Heeba, G., Abolnaga, M., Othman, E. (2023). 'RECENT APPROACHES FOR SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITORS IN THE MANAGEMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE', test, 46(1), pp. 579-595. doi: 10.21608/bfsa.2023.301257
Heeba, G., Abolnaga, M., Othman, E. RECENT APPROACHES FOR SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITORS IN THE MANAGEMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE. test, 2023; 46(1): 579-595. doi: 10.21608/bfsa.2023.301257

RECENT APPROACHES FOR SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITORS IN THE MANAGEMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE

Bulletin of Pharmaceutical Sciences Assiut University
Volume 46, Issue 1, June 2023, Pages 579-595    PDF (1.18 M)
Document Type: Original Article
DOI: 10.21608/bfsa.2023.301257
Authors
Gehan H. Heeba* 1; Mohamed Y. Abolnaga2; Eman M. Othman2
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, El-Minia, Egypt
2Department of Biochemistry, Faculty of Pharmacy, Minia University, El-Minia, Egypt
Abstract
NAFLD is an umbrella term for a variety of illnesses of ranging severity starts with simple steatosis, develops to non-alcoholic steatohepatitis (NASH), then cirrhosis, and if not controlled, eventually can develop to fibrosis and even hepatocellular carcinoma (HCC). The disease is linked to obesity, insulin resistance, and type 2 diabetes mellitus (T2DM), thus addressing these interconnected disorders could be an effective approach for its management.
This review gives an overview the most recent relevant research studies and the on-going therapeutic options for NAFLD focusing on the recently discovered sodium glucose cotransporter 2 inhibitors (SGLT2i), the new antihyperglycemic class of drugs which recently gained adequate popularity, as well as their efficacy and applications in experimental and clinical work.
Keywords
Non-alcoholic fatty liver disease; Sodium glucose co-transporter 2 inhibitors, Insulin resistance, oxidative stress
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