SAFETY OF BEE VENOM PREPARATION FOR MARKETING STRATEGY | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 19, Volume 53, Issue 2, August 2023, Pages 359-368 PDF (1.36 M) | ||
| DOI: 10.21608/jesp.2023.312180 | ||
| Authors | ||
| ABIR A. ELFIKY1; SHERIF S. ELFEEL1; SHOROUK R. AHMED2; MAY I. KATAKET2; TOSSON A. MORSY3 | ||
| 1VASCERA Holding Company for Biological Products & Vaccines, Giza P.O.Box, 276, Postal Code, 12311 | ||
| 2Faculty of Biotechnology October University for MSA, Giza | ||
| 3Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt | ||
| Abstract | ||
| Bee venom is very popular; being a natural treatment with multiple medicinal effects for several diseases. Research continues to endorse and reveal more of its benefits on human health. This study assessed the safety of bee venom aqueous preparation by hematological, biochemical and histopathological examinations. 20 male rabbits classified into control and test; were given multiple bee venom intradermal injections according to a specific immunization schedule adopted by VACSERA for 6 months and compared with control group injected with saline. The hematological results showed improving in the red blood cells integrity leading to an increase in erythron count. But, leukon showed a non-significant increase, yet lymphocytic count significantly increased. Biochemical parameters revealed significant increase in total protein and albumin within normal level accompanied with non-significant hyperglobulinemia. Total bilirubin, direct bilirubin, aspartate transaminase, gamma glutamyl transferase, serum Iron level, creatine phosphokinase and lactate dehydrogenase showed non-significant change, however serum creatinine showed significant decrease. The histopathological findings showed normal picture of liver, kidney, spleen tissues and heart muscles. The skin showed local allergic reaction but only at the site of injection. From the aforementioned results bee venom was considered as a safe medication. | ||
| Keywords | ||
| Egypt; Bee venom; Rabbits; Safety | ||
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