Emara, E., El-Sawaf, M., Khalifa, R. (2022). The Toxic Effect of Some Newly Constructed Diaminodiphenylmethane Derivatives Applied In Vitro and In Vivo Trials against Theba Pisana in Relation to Mucus Secretion. test, 14(1), 283-293. doi: 10.21608/eajbsf.2022.312254
Esam M. Emara; Maher A. El-Sawaf; Rasha F. Khalifa. "The Toxic Effect of Some Newly Constructed Diaminodiphenylmethane Derivatives Applied In Vitro and In Vivo Trials against Theba Pisana in Relation to Mucus Secretion". test, 14, 1, 2022, 283-293. doi: 10.21608/eajbsf.2022.312254
Emara, E., El-Sawaf, M., Khalifa, R. (2022). 'The Toxic Effect of Some Newly Constructed Diaminodiphenylmethane Derivatives Applied In Vitro and In Vivo Trials against Theba Pisana in Relation to Mucus Secretion', test, 14(1), pp. 283-293. doi: 10.21608/eajbsf.2022.312254
Emara, E., El-Sawaf, M., Khalifa, R. The Toxic Effect of Some Newly Constructed Diaminodiphenylmethane Derivatives Applied In Vitro and In Vivo Trials against Theba Pisana in Relation to Mucus Secretion. test, 2022; 14(1): 283-293. doi: 10.21608/eajbsf.2022.312254

The Toxic Effect of Some Newly Constructed Diaminodiphenylmethane Derivatives Applied In Vitro and In Vivo Trials against Theba Pisana in Relation to Mucus Secretion

Egyptian Academic Journal of Biological Sciences, F. Toxicology & Pest Control
Volume 14, Issue 1, June 2022, Pages 283-293    PDF (727.97 K)
Document Type: Original Article
DOI: 10.21608/eajbsf.2022.312254
Authors
Esam M. Emara1; Maher A. El-Sawaf1; Rasha F. Khalifa2
1Harmful Animals Department, Plant Protection Research Institute, Agricultural Research Center, Dokki, Giza, Egypt.
2Econ. Entomology and Agric. Zoology Deptr., Faculty of Agric., Menoufia University.
Abstract
The condensation reaction between diaminodiphenylmethane (MDA) and methomyl afforded the HL ligand. Cu (II) and Zn (II) chloro complexes of this ligand were prepared and their structures were elucidated by using some analytical and spectral methods. The thin-layer film method was used to assess the toxicity of the obtained compounds against Theba pisana species under laboratory conditions. The obtained data showed a remarkable toxicological activity of the achieved compounds. The tested compounds caused alternations in the quantity of the mucus secretions of the tested species after treatments leading to snail mortality. The achieved lab data authenticated the elevated toxicological impact of Zn (II) chelate on Theba pisana species (LC50 = 52.97 ppm). The white garden snail showed a considerable susceptibility to the HL ligand and Cu (II) complex (LC50 = 56.89 and 85.53 ppm, respectively). Field trials were conducted by spraying method and the population reduction percentage of the white garden snail was assessed. The obtained field trial results were compatible with those of laboratory tests. The tested compounds displayed significant reduction percentages of Theba pisana population after 7, 14, and 21 days of treatments. The HL ligand, Cu (II) and Zn(II) complexes recorded  94.47, 95.58 and 96.04%, respectively, as reduction percentages in Theba pisana population after 21 days of treatments under field conditions. 
Keywords
MDA derivatives; Theba pisana; Mucus secretion; In vitro assessment; In vivo evaluation
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