Estimation of Osteoprotgrin Level in B Thalassemia Children | ||
| Benha Medical Journal | ||
| Article 23, Volume 40, Issue 2, September and October 2023, Pages 566-577 PDF (822.84 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2023.213665.1830 | ||
| Authors | ||
| Noura Abd Elhaleem Abd Elhameed Ibrahim* 1; Shahen Ali Dabour2; Rana Atef Khashaba3; Aliaa Mohammed Elhady4 | ||
| 1Department of Pediatrics , Faculty of Medicine, Benha University, Benha, Egypt | ||
| 2Department of pediatrics ,Faculty of Medicine Benha University. | ||
| 3Department of Clinical pathology faculty of medicine benha university Egypt | ||
| 4Department of Pediatrics, Faculty of Medicine, Benha University, Benha. Egypt | ||
| Abstract | ||
| Background: Beta-thalassemia major (B-TM) is a genetic disorder characterized by impaired hemoglobin synthesis, leading to hemolytic anemia and associated complications. This study aimed to assess the diagnostic value of serum Osteoprotegerin (OPG) as an early biomarker for osteoporosis in B-TM children. Patients and Methods: A cross-sectional study was conducted at the Pediatric Department of Benha University Hospital from January 2022 to December 2022. The study included 64 children aged 2 to 18 years, divided into two groups: Group 1 consisted of 40 children with β-thalassemia (cases group), and Group 2 consisted of 24 age and sex-matched healthy children (control group). Various parameters including Hb, OPG, vitamin D3, and ferritin were measured using enzyme-linked immune sorbent assay. Result: The study also examined the relationship between these biomarkers, Body Mass Index (BMI), and splenic status. The results showed significantly decreased levels of Hb, and vitamin D3 in β-thalassemic patients compared to the healthy group (P | ||
| Keywords | ||
| Beta-thalassemia major (B-TM); serum Osteoprotegerin (OPG); osteoporosis; Vitamin D3 | ||
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