Vancomycin-Resistant Staphylococcus aureus Causing Ocular Infections in El-Gharbia Governorate, Egypt | ||
| Egyptian Journal of Veterinary Sciences | ||
| Volume 54, Issue 7, November and December 2023, Pages 77-85 PDF (1.03 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2023.230168.1564 | ||
| Authors | ||
| Amgad A. Moawad1; Lamiaa M. Eissa2; Abdelgayed M. Younes* 3; Soliman A. Haroun2 | ||
| 1Bacteriology, Mycology and Immunology Department, Faculty of Veterinary medicine, Kafrelsheikh University, Kafr El-Sheikh 33516, Egypt. | ||
| 2Department of Botany and Microbiology, Faculty of Science, Kafrelsheikh University, Egypt | ||
| 3Hydrobiology Department, Veterinary Research Division, National Research Centre, El Buhouth St., Dokki, 12311 Cairo (Egypt) | ||
| Abstract | ||
| Ocular infections caused by bacteria and their complications represent an important public health problem worldwide. The study was conducted to determine the antimicrobial resistance pattern and the emergence of cefoxitin- and vancomycin-resistant S. aureus causing ocular infections at El-Gharbia governorate hospitals. We collected 300 S. aureus causing ocular isolates from patients suffering from eye infections from four hospitals at El-Gharbia governorate, and the isolates were molecularly characterized using 23s rRNA PCR. Antibiotic sensitivity tests were performed using the disk diffusion test. A total of 90 (31%) S. aureus ocular isolates were identified, and distributed within the four hospitals as 25%, 33%, 48%, and 16% from Quotour hospital, El–Menshawy, El-Ramad and Quotour clinic, respectively. Moreover, S. aureus was isolated with 30.8 % and 31 % male and female patients. S. aureus ocular isolates were sensitive to ciprofloxacin, levofloxacin, cefuroxime, amikacin, azithromycin, norfloxacin, sulbactam/ampicillin and cefotaxime. In contrast, 89%, 90%, 100% and 85% of these isolates showed resistance to ampicillin, cefoxitin, doxycycline hydrochloride, and vancomycin. Whereas, the rest of S. aureus strains were cefoxitin- and vancomycin-intermediate resistant. This study alerts the emergence of cefoxitin- and vancomycin-resistant S. aureus causing ocular infections among hospitals in the El-Gharbia governorate. Additionally, ciprofloxacin is the most effective antibiotic against S. aureus causing ocular infections reported in this study. | ||
| Keywords | ||
| Ophthalmic infections; Staphylococcus aureus; Vancomycin resistance; Methicillin resistance | ||
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