Association Between Vitamin D Deficiency and Unexplained Infertility | ||
| Evidence Based Women's Health Journal | ||
| Article 4, Volume 13, Issue 4, November 2023, Pages 328-333 PDF (370.83 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ebwhj.2023.211176.1249 | ||
| Authors | ||
| Ahmed Ramy; Tarek Rafaat; Ahmed Abdel Hameed; Ikran Haji* | ||
| Obstetrics and gynecology faculty of medicine Ain shams university Egypt | ||
| Abstract | ||
| Background: The causes of female infertility are different and include genetic and anatomic abnormalities as well as endocrine and autoimmune disorders (ADs). Vitamin D might influence steroidogenesis of both estradiol and progesterone in healthy women where low levels of 25(OH)D levels might be associated with infertility. Aim of the Work: To elucidate if there is relationship between vitamin D and unexplained infertility and if it more prevalent in them. Patients and Methods: This case-control study was conducted at Ain Shams University Maternity Hospital during the period between October 2018-april 2019. A total of 70 women with prior history of unexplained infertility were included as group A (study group). A Second set of 70 fertile control group were included as group B (control group). Results: Our study indicated that 25(OH) vitamin-D was significant lower in unexplained infertility group than control group (according to vitamin D level 39 out of 70 in unexplained infertility patient (55.7) had deficiency, while 30(42.9%) had insufficiency and 1(1.4) had sufficiency, in comparison to control group 21(30.0%) had deficiency, while 43(61.4) had insufficiency and 6(8.6%) had sufficiency), there were no significant correlation between 25(OH) vitamin D and age and BMI. Conclusion: Vitamin-D deficiency had a role in unexplained infertility, nevertheless it is not a good diagnostic test. Unexplained infertility is multifactorial; Vit-D is only one of many factors/ theories. | ||
| Keywords | ||
| Subfertility; unexplained infertility; vitamin D deficiency | ||
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