Effects of chronic uncontrolled hyperglycemia on neuroglial population of CA3 region of hippocampus: A study by TEM | ||
| Journal of Medical Histology | ||
| Article 2, Volume 6, Issue 2, December 2022, Pages 129-133 PDF (384.63 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jmh.2023.179072.1109 | ||
| Author | ||
| Shahriar Ahmadpour* | ||
| Department of Anatomy & Neuroanatomy, Anatomical Sciences, Medicine School, North Khorasan University of Medical Sciences, Bojnurd, Iran. | ||
| Abstract | ||
| Introduction: Altered function of astrocytes has been noticed in diabetes mellitus type 1. Aims: This study was carried out to determine the effects of chronic uncontrolled hyperglycemia on neuroglial elements of the CA3 region of hippocampus. Materials and Methods: Diabetes was induced in adult male wistar rats by application of streptozotocin (60mg/kg). After 8 weeks, the hippocampi were removed and the number of astrocytes and degenerated neurons in CA3 were studied using transmission electron microscopy. Results: The astrocytes exhibited structural changes, including reduced electron density of the nucleus, electro-lucent heterochromatin, and vacuolated cytoplasm. The mean number of astrocytes in the CA3 region of diabetic group (7±2) showed a significant increase compared to the control group (P<0.05). The number of degenerated neurons in the diabetic animals showed significant level of difference in comparison with control (p < 0.05). Conclusion: Our data revealed that chronic diabetes mellitus type 1is associated with increase in the mean number of astrocytes and ultrastructural astrocyte changes in the CA3 region of hippocampus. | ||
| Keywords | ||
| Hippocampus; hyperglycemia; neuroglial; TEM | ||
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