Wageh, A., Nagib, R., Eid, M. (2019). Placenta Of Late Onset Preeclampsia Without Fetal Growth Restriction : Is It Different From The Normal?. test, 9(2), 399-406. doi: 10.21608/ebwhj.2019.33481
Alaa Wageh; Reham Mohamed Nagib; Mohamed Ibrahim Eid. "Placenta Of Late Onset Preeclampsia Without Fetal Growth Restriction : Is It Different From The Normal?". test, 9, 2, 2019, 399-406. doi: 10.21608/ebwhj.2019.33481
Wageh, A., Nagib, R., Eid, M. (2019). 'Placenta Of Late Onset Preeclampsia Without Fetal Growth Restriction : Is It Different From The Normal?', test, 9(2), pp. 399-406. doi: 10.21608/ebwhj.2019.33481
Wageh, A., Nagib, R., Eid, M. Placenta Of Late Onset Preeclampsia Without Fetal Growth Restriction : Is It Different From The Normal?. test, 2019; 9(2): 399-406. doi: 10.21608/ebwhj.2019.33481

Placenta Of Late Onset Preeclampsia Without Fetal Growth Restriction : Is It Different From The Normal?

Evidence Based Women's Health Journal
Article 2, Volume 9, Issue 2, May 2019, Pages 399-406    PDF (1.3 M)
Document Type: Original Article
DOI: 10.21608/ebwhj.2019.33481
Authors
Alaa Wageh* 1; Reham Mohamed Nagib2; Mohamed Ibrahim Eid3
1Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Egypt.
2Department of Pathology, Faculty of Medicine, Mansoura University, Egypt.
3Department of Obstetrics and Gynecology, Faculty of Medicine, Mansoura University, Egypt
Abstract
Background: Preeclampsia (PE) is one of the most common pregnancy complications affecting approximately 5-7% of pregnant women worldwide. Pathogenesis of PE is still mysterious. Literature studies reported differences between early and late onset PE. Also, whether placenta of late-onset PE without fetal growth restriction (FGR) is different from normal one needs further declaration.
Objective: This study aims at evaluating the placental microvessel density (MVD), apoptosis and endoglin (CD105) expression in late-onset PE without FGR.
Patients and Methods: Placentae of 15 PE and 15 matched control ones were evaluated grossly, microscopically and by immunohistochemistry for caspase-3, CD 34 and CD105.
Results: Placentas in PE group showed a statistically significant difference as regard size, syncytial knots, perivillous fibrin deposition, villous infarction increased apoptosis, and endoglin (CD105) expression. However, the percentage of terminal villi and microvessel density (MVD) were comparable in both groups.
Conclusion: Placenta from late onset PE without FGR is still different from the normal placenta whatever time onset of PE pathogenesis may be similar. Absence of changes in MVD may explain good fetal outcome.
Keywords
apoptosis; Caspase-3; CD 34; CD105; Pre-eclampsia
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