Influence of Infugem on the Histology, Biochemistry, and Hematology of Liver and Kidneys of Pregnant Albino Mice | ||
| Egyptian Journal of Histology | ||
| Article 15, Volume 48, Issue 1, March 2025, Pages 236-244 PDF (1.36 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejh.2024.242084.1964 | ||
| Authors | ||
| Baidaa Abduaaziz Mohamed Salah* ; Mohammed Younes Alfathi | ||
| Department of Biology, College of Education for Pure Science, University of Mosul, Mosul, Iraq | ||
| Abstract | ||
| Introduction: Infugem is a highly promising cure for various cancerous tumors, such as urinary, pulmonary, breast, and throat carcinoma The drug has many side effects on various organs in the body. Aim of the Study: The objective of this investigation was to determine how two doses 60 and 120 mg/kg of the infugem drug would affect some maternal organs (liver and kidney), certain serum biochemical markers, and hematology. The drug was given during the pregnancy period for three days) those days were 9th,13th, and 16th). Materials and Methods: 30 pregnant mice were used. The animals were separated into three sets. The control (set I) was injected with normal saline. Sets II and III were injected intraperitonally (IP) with infugem (60 and 120 mg/kg of b.w., respectively) during pregnancy. The histopathological changes of the maternal liver, kidney, blood biochemistry, and hematology were conducted. Prism software was used in the statistical assessment. Results: The results showed numerous apparent histopathological changes at both doses like degeneration, necrosis in the liver, (and glomerulitis in the kidney the severity of the lesions was a dose-dependent manner. The maternal hematological (RBCs, WBC, Hb, PLT, HCT) and biochemical (AST, ALT, ALP, BUN, Uric acid, Total protein, Total bilirubin, Glucose) parameters showed significant changes at both selected doses. Conclusions: The drug harmed the histology and functions of the mice's maternal liver and kidneys, and the drug caused significant changes in the maternal blood components. | ||
| Keywords | ||
| Anticancer; blood toxicity; histopathology; infiltration | ||
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