Deiab, N., Kodous, A., Mahfouz, M., Said, A., abouzaid, O. (2023). Ameliorative Effect of Novel Nanocompound against Oxidative Stress- Induced Brain Toxicity in Mice. test, 45(2), 61-65. doi: 10.21608/bvmj.2023.255548.1765
Nora Samy Deiab; Ahmad Shehata Kodous; Mohamed Mahfouz; Alshaimaa Mohammed Said; omayma ahmed abouzaid. "Ameliorative Effect of Novel Nanocompound against Oxidative Stress- Induced Brain Toxicity in Mice". test, 45, 2, 2023, 61-65. doi: 10.21608/bvmj.2023.255548.1765
Deiab, N., Kodous, A., Mahfouz, M., Said, A., abouzaid, O. (2023). 'Ameliorative Effect of Novel Nanocompound against Oxidative Stress- Induced Brain Toxicity in Mice', test, 45(2), pp. 61-65. doi: 10.21608/bvmj.2023.255548.1765
Deiab, N., Kodous, A., Mahfouz, M., Said, A., abouzaid, O. Ameliorative Effect of Novel Nanocompound against Oxidative Stress- Induced Brain Toxicity in Mice. test, 2023; 45(2): 61-65. doi: 10.21608/bvmj.2023.255548.1765

Ameliorative Effect of Novel Nanocompound against Oxidative Stress- Induced Brain Toxicity in Mice

Benha Veterinary Medical Journal
Volume 45, Issue 2, December 2023, Pages 61-65    PDF (394.39 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2023.255548.1765
Authors
Nora Samy Deiab* 1; Ahmad Shehata Kodous2; Mohamed Mahfouz1; Alshaimaa Mohammed Said3; omayma ahmed abouzaid1
1Biochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Benha University, Benha, Al Qalyubiyah, Egypt
2Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, P.O. Box 13759, Egypt. Molecular Oncology Department - Cancer Institute (WIA), 38 Sardar Patel Road
3Biochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Benha University
Abstract
This study investigates the antioxidant properties of pH-responsive chitosan-based poly (acrylamide/acrylic acid) hesperidin (Cs/P(AAc/AAm)/HSP) Nanogel in AlCl3+NaF-intoxicated mice brain tissues as a pre-treatment and post-treatment agent. Fifty adult male Albino mice were used in our study, and were divided equally into 5 groups of (Ⅰ) normal control, (Ⅱ) Cs/P(AAc/AAm)/HSP, (Ⅲ) AlCl3+NaF, (Ⅳ) pre-treatment (prophylaxis), (Ⅴ) post-treatment (therapeutic). We used the colorimetric technique to detect the concentrations of MDA and GSH as well as the activity of SOD and GPx. AlCl3+NaF induced severe neurotoxicity and oxidative stress in mice brain tissue, manifested by the marked changes in the studied parameters. Either pre- or post-Cs/P(AAc/AAm)/HSP oral administration ameliorated these changes, as demonstrated by the significant reduction in MDA concentration, and increased GSH levels. Additionally, Cs/P(AAc/AAm)/HSP restored the activity of SOD and GPx enzymes, indicating mitigation of the induced oxidative stress. Our findings from this study clearly showed the antioxidant potential of Cs/P(AAc/AAm)/HSP either as a prophylactic or therapeutic agent against AlCl3+NaF-induced brain damage.
Keywords
Fluoride; Aluminum; Hesperidin; Neurotoxicity
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