(2018). A study on the effects of rotenone on the midbrain in the adult male albino rats. test, 22(3), 321-326. doi: 10.21608/smj.2018.35037
. "A study on the effects of rotenone on the midbrain in the adult male albino rats". test, 22, 3, 2018, 321-326. doi: 10.21608/smj.2018.35037
(2018). 'A study on the effects of rotenone on the midbrain in the adult male albino rats', test, 22(3), pp. 321-326. doi: 10.21608/smj.2018.35037
A study on the effects of rotenone on the midbrain in the adult male albino rats. test, 2018; 22(3): 321-326. doi: 10.21608/smj.2018.35037

A study on the effects of rotenone on the midbrain in the adult male albino rats

Sohag Medical Journal
Article 38, Volume 22, Issue 3, October 2018, Pages 321-326    PDF (161.1 K)
Document Type: Original Article
DOI: 10.21608/smj.2018.35037
Abstract
Background aims. Rotenone is a widely used insecticide has a neurodegenerative effect on the dopaminergic cells of substantia nigra (SN) of midbrain producing Parkinsonism. The aim of this study is to study the effects of rotenone when injected subcutaneously on the dopaminergic cells of the substantia nigra of the midbrain.
Methods.The effects of rotenone on the SN of midbrain and the were determinedhistopathologically, immunohistochemically, and by transmission electron microscopy. Results. Subcutaneous rotenone produced Parkinsonism through producing degeneration of the dopaminergic cells of SN of the midbrain. Conclusion. These results indicate that, rotenone has a neurodegenerative effect on the dopaminergic cells of the substantia nigra of the midbrain producing parkinsonism.
Keywords
Dopaminergic neurons; Neurodegeneration; parkinsonism; Rotenone; Substantia nigra
References
  1. Wood DM, Alsahaf H, Streete P, Dargan PI, and Jones AL (2005): Fatality after deliberate ingestion of the pesticide rotenone: a case report. Crit Care; 9(3):280–284. 
  2.  Tanner CM, Kamel F, Ross  GW, Hoppin JA, Goldman SM, Korell M; Marras C, Bhudhikanok GS,  Kasten M, Chade AR, Comyns K, Richards MB, Meng C, Priestley B, Fernandez HH, Cambi F, Umbach DB, Blair A, Sandler DP and Langston JW. (2011): Rotenone, Paraquat and Parkinson’s Disease. Environmental Health Perspectives; 119 (6): 866–872. 
  3. Markham A, Cameron I and Bains R. (2012):  Brain-derived neurotrophic factor-mediated effects on mitochondrial respiratory coupling and neuroprotection share the same molecular signalling pathways. Eur J Neurosci; 35:366–374.
  4. .Ren Y and Feng J. (2007): Rotenone selectively kills serotonergic neurons through a microtubule-dependent mechanism. J Neurochem; 103:303-311.
  5.   A, Monser L and Adhoum N. (2010): Removal of rotenone insecticide by adsorption onto chemically modified activated carbons. J Hazard Mater; 181:692-699.
  6. .   Gomez C, Bandez MJ and Navarro A. (2007): Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome. Front Biosci; 12:1079–1093.
  7. . Wirdefeldt K, Adami HO, Cole P, Trichopoulos D and Mandel J. (2011): Epidemiology and etiology of Parkinson’s disease: a review of the evidence. Eur J Epidemiol; 26:1–58.
  8.  Jankovic J. (2008): Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psych; 79:368–376.
  9. . Alves G, Forsaa EB, Pedersen KF, Dreetz Gjerstad, and Larsen M. (2008): Epidemiology of Parkinson's disease. J Neurol; 255:18–32.
  10.  Joers V and Emborg M. (2009): Preclinical assessment of stem cell therapies for neurological diseases. ILAR J; 51:24–41.
  11. Karin W, Hans-Olov A, Philip C, Dimitrios T and Jack M. (2011): Epidemiology and etiology of Parkinson’s disease: a review of the evidence. Eur J Epidemiol; 26:1-58.
  12. Sadeghian M, Marinova-Mutafchieva L, Broom L, Davis J, Virley D and Medhurst A. (2012): Full and partial peroxisome proliferation-activated receptor-gamma agonists, but not delta agonist, rescue of dopaminergic neurons in the 6-OHDA parkinsonian model is associated with inhibition of microglial activation and MMP expression. J Neuroimmunol; 246:69–77. 
  13.  Horsfall L,  Petersen I,  Walters K and Schrag A. (2013): Time trends in incidence of Parkinson’s disease diagnosis in UK primary care. J Neurol; 260:1351-1357.
  14.  Lesage S and Brice A. (2009): Parkinson's disease: From monogenic forms to genetic susceptibility factors. Hum Mol Genet; 18:48–59.
  15.  Zaitone SA, Abo- Elmatty DM and Elshazly SM. (2012):Piracetam and vinpocetine ameliorate rotenone induced Parkinsonism in rats. Indian J Pharmacol; 44:774-779.
  16.  Budde MD, Kim JH, Liang HF, Schmidt RE, Russell JH and Cross AH. (2007): Toward accurate diagnosis of white matter pathology using diffusion tensor imaging. Magn Reson Med; 57:688–695.
  17.  Lennington JB, Pope S, Goodheart AE, Drozdowicz L, Daniels SB and Salamone JD. (2011): Midbrain dopamine neurons associated with reward processing innervate the neurogenic subventricular zone. J Neurosci; 31:13078-13087.
  18. . Watabe-Uchida M, Zhu L, Ogawa SK, amanrao A and Uchida N. (2012): Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons. Neuron; 74:858-873.
  19.  Wrangel CV, Schwabe K, John N, Krauss JK and Alam M. (2015): The rotenone-induced rat model of Parkinson's disease: Behavioral and electrophysiological findings. Behav Br Res; 279:52-61.
  20.  Wood DM, Alsahaf H, Streete P, Dargan PI, and Jones AL (2005): Fatality after deliberate ingestion of the pesticide rotenone: a case report. Crit Care; 9(3):280–284.
  21. Schuler F and Casida JE (2001): Functional coupling of PSST and ND1 subunits in NADH: ubiquinone oxidoreductase established by photo affinity labeling. Biochem Biophys Acta; 1506:79–87.
  22. Pan T, Rawal P, Wu Y, Xie W, Jankovic J and Le W. (2009): Rapamycin protects against rotenone-induced apoptosis through autophagy induction. Neurosci; 164: 541-551.
  23.  Alam A and Schmidt WJ (2002): Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats. Behav Brain Res; 136:317–324.
  24. Kim H, Park H, Park H and Chung J. (2009): Tranexamic acid protects against rotenone induced apoptosis in human neuroblastoma SH-SY5Y cells. Toxicol; 262:171–174.
  25. Barreto GE (2012): Mitochondrial functions in astrocytes: neuroprotective implications from oxidative damage by rotenone. Neurosci Res; 74:80–90.

 

 

 

 

 

 

 

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