PREVALENCE AND ASSOCIATED RISK FACTORS OF NON-ALCOHOLIC FATTY LIVER DISEASE IN ELDERLY EGYPTIAN PATIENTS | ||
| ALEXMED ePosters | ||
| Article 1, Volume 6, Issue 2, April 2024, Pages 7-8 | ||
| Document Type: Preliminary preprint short reports of original research | ||
| DOI: 10.21608/alexpo.2024.283417.1824 | ||
| Authors | ||
| Mohamed Mehanna1; Nany Hassan Algiar2; Reem Said Shaala1; Hana Ali Donia3; Ahmed Mohammed Mohammed ‎Hafez* 4 | ||
| 1Department of Internal Medicine, Faculty of Medicine, Alexandria University | ||
| 2Department of Internal Medicine, Faculty of Medicine - Alexandria University | ||
| 3Clinical Pathology Department, Faculty of Medicine; Alexandria University, Egypt. | ||
| 4Department of Internal Medicine,Faculty of Medicine, Alexandria University | ||
| Abstract | ||
| INTRODUCTION Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in the general population worldwide. Most individuals with NAFLD have components of metabolic syndrome (MS) such as type 2 diabetes (T2D), dyslipidemia, hypertension and visceral obesity. Although gender-specific differences in the prevalence of NAFLD have been debated, increasing age does seem to have an influence by increasing the prevalence of NAFLD. However, the age cut-off chosen for the definition of “elderly” may vary across the studies, yielding conflicting results. In fact, while most studies reported an increased prevalence and severity of NAFLD in subjects older than 60 or 65 years, NAFLD appear to be a common but benign finding in an octogenarian population with a prevalence rate of 46.2% . Age-related anatomical and functional changes in the liver can also impact the progression and outcomes of liver disease. In fact, older individuals lose nearly one third of their hepatic volume and perfusion, which may negatively affect the regenerative capacity of the liver. In addition to the age-related lipid accumulation in non-adipose tissue, including liver, older age is also associated with sarcopenia, i.e. decreased muscle mass and function, along with dysregulation of the free radical scavenging systems which can lead to an increase in the oxidative stress potentially promoting the progression of NAFLD. | ||
| Keywords | ||
| PREVALENCE; NON-ALCOHOLIC FATTY LIVER DISEASE ; ELDERLY EGYPTIANS | ||
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