Role Of Serum Hepcidin as A Diagnostic and Prognostic Marker For Sepsis among Critically ill Patients | ||
| Zagazig University Medical Journal | ||
| Volume 30, Issue 5, August 2024, Pages 1783-1792 PDF (810.64 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2024.285207.3354 | ||
| Authors | ||
| Ahmed Noaman Elsayed1; Yaser A A El hendy2; Islam Ehab* 3; Ghada Elsayed Amr4; Amira Hamed Mohamed Afifi5; Michael Edwar3; Usama Ragab6 | ||
| 1Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt | ||
| 2Internal medicine, faculty of medicine zagazig University zagazig Egypt | ||
| 3Internal Medicine Department, Faculty of Medicine, Zagazig University | ||
| 4Department of Clinical Pathology, Faculty of Medicine – Zagazig University, Egypt | ||
| 5clinical pathology faculty of medicine zagazig univeristy | ||
| 6Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt. | ||
| Abstract | ||
| Background: In the last decade hepcidin which was previously known to have a significant role in iron metabolism, has gained attention as a possible marker of bacterial sepsis in adults. This research aimed to evaluate the role of hepcidin as a biomarker for diagnosis and prognosis of sepsis among critically ill patients. Methods: In a cohort study, 62 emergency medical patients who were admitted to the ICU within 24 hours and were divided into two groups: those with sepsis (Group A) and those without (Group B). Hepcidin levels were measured using an ELISA kit, and patient assessments included SOFA, SAPS 3, and APACHE II scores. Results: Septic patients had significantly higher hepcidin than the non-septic patients (p<0.001). Hepcidin was a significant diagnostic marker for sepsis with sensitivity (91.89%) and specificity (70.97%) at cutoff point of 2.52 ng/ml with AUC was (0.922). Multivariate regression analysis revealed that alongside traditional sepsis markers, hepcidin and SAPS3 scores were independent predictors of mortality, with ORs of 2.09 (95% CI: 1.31–3.33, p=0.002) and 1.21 (95% CI: 1.04–1.4, p=0.01), respectively. Conclusion: Serum hepcidin, combined with clinical scoring systems, proves to be a reliable diagnostic tool for sepsis and could serve as a predictor of mortality in critically ill septic patients. | ||
| Keywords | ||
| Serum Hepcidin; Predictor; Mortality; Sepsis; critically ill | ||
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