The relationship between 18F FDG PET CT volumetric parameters and pathological factors in metastatic breast cancer | ||
| Egyptian Journal Nuclear Medicine | ||
| Volume 24, Issue 1, June 2022, Pages 39-51 PDF (540.88 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/egyjnm.2022.133171.1058 | ||
| Authors | ||
| Maha Abd Elkareem Husseini* 1; Nourhan Kotb Nasr2; Ahmed Abdel Hafeez Mohamed3; Mahasen Amin Abougabal4 | ||
| 1Nuclear medicine unit. Department of radiotherapy and nuclear medicine (NEMROCK) , nuclear medicine unit , Kasr Al-Ainy Hospital , Cairo University | ||
| 2Nuclear medicine unit. Department of radiotherapy and nuclear medicine (NEMROCK) , Kasr Al-Ainy Hospital , Cairo University | ||
| 3Oncology unit. Oncology and Nuclear Medicine Department (NEMROCK), Kasr Elainy Hospital, Cairo University. | ||
| 4Professor of Nuclear Medicine Department of radiotherapy and nuclear medicine (NEMROCK) , Kasr Al-Ainy Hospital , cairo University | ||
| Abstract | ||
| Objective: Assess correlation between the 18F FDG PET/CT volumetric parameters and clinico-pathological prognostic factors in metastatic breast cancer Methods: In this prospective study we included 52 patients who underwent F18 FDG PET/CT with metastases to loco/regional lymph nodes, distant metastases were detected in 22 of them. The association of maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), tumour/liver uptake ratio (TLR) and total lesion glycolysis (TLG) of the loco/regional lymph nodes and distant metastases with clinico-pathological prognostic factors were assessed. Results: There were significant correlations between regional lymph nodes metastases SUVmax and SUVmean and tumor grade & N stage , while no significant correlation was found regarding the other parameters including focality of the primary tumor , histology , ER , PR , HER2 , KI67 , molecular subtype and M stage. On the other hand regional lymph nodes metastases MTV, TLG and TLR, correlation was found regarding N stage only and no significant correlation was found regarding the other parameters. No significant correlations between volumetric parameters of bone metastases and clinic-pathological risk factors could be elicited. Conclusion: Volumetric parameters of the metastatic loco-regional lymph nodes in breast cancer can reflect aggressiveness of the tumor, therefore can help in therapy planes, while this not found regarding bone metastases. | ||
| Keywords | ||
| Metastatic breast cancer; PET/CT; Pathological risk factors | ||
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