Is it Possible to Use Diffusion weighted MRI to Distinguish and Discriminate between Pathological Subtypes of Benign and Malignant Thyroid Nodules ? | ||
| Medicine Updates | ||
| Volume 19, Issue 19, October 2024, Pages 55-70 PDF (1.42 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/muj.2024.303633.1176 | ||
| Authors | ||
| Waleed Said Abo Shanab1; Mohamed Elrakhawy2; Carmen Ali Zarad1; Amr Abo elfarh* 3; Khaled Abd El-Baky Ahmed4 | ||
| 1Associate professor of Diagnostic Radiology, Faculty of Medicine, Port Said University, Egypt | ||
| 2Faculty of medicine Mansoura University | ||
| 3Radiology Department, Suez Canal Authority, Port Said, Egypt | ||
| 4Lecturer of Diagnostic Radiology, Faculty of Medicine, Port Said University, Egypt | ||
| Abstract | ||
| Background: Fine needle aspiration cytology (FNAC) is an accurate technique for diagnosis of thyroid nodules, however, 10% are non-diagnostic. As a result, there is a need for an alternative diagnostic technique. Water molecular motion in lesions and healthy tissues can be quantitatively measured with the help of diffusion-weighted imaging (DWI). The net diffusion of the water molecules is expressed in terms of the apparent diffusion coefficient (ADC). Aim of the study: Our goal was to evaluate the usefulness of ADC values in differentiating malignant from benign thyroid nodules, as well as pathological subtypes of each group with FNAC correlation. Materials and methods: Seventy patients with 70 thyroid nodules were included in this prospective study done during the period between January 2022 and March 2024. Each patient's thyroid gland nodules were examined by diffusion-weighted imaging then intended to have ultrasound guided FNAC. Results: The mean ADC value for the benign group is higher than that for malignant nodules. The mean ADC at b = 1000 was 1.02 ± 0.381 in benign lesions but in malignant lesions it was 0.73 ± 0.323 with a statistical significant difference in between P<0.001. We observed a considerable overlapping in ADC values of different pathological sub types within each group of either malignant or benign nodules with a statistically insignificant difference (P value ranged from 0.056 to 0.063). Conclusions: ADC values can be used to discriminate benign from malignant thyroid nodules; however it is not possible to distinguish between several histological subtypes of each group. | ||
| Keywords | ||
| Apparent diffusion coefficient value; Diffusion MRI; Fine needle aspiration cytology; Thyroid nodules | ||
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