Role of Serum Clusterin in Bronchial Asthma | ||
| Ain Shams Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 October 2024 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asmj.2023.206246.1116 | ||
| Authors | ||
| Heba Adel Abou Zaghla* 1; Mona Fathy2; Shorouk Ayman Ahmed3; Zeinab Ashour4; Marium ElSayed Fathi5 | ||
| 1Clinical Pathology department Faculty of medicine Ain shams university | ||
| 2clinical pathology, faculty of medicine, ain shams university. cairo , egypt | ||
| 3clinical pathology department Faculty of medicine Ain shams university | ||
| 4Internal Medicine Department, Allergy and clinical immunology | ||
| 5Clinical pathology department Faculty of medicine Ain shams university | ||
| Abstract | ||
| Background: Bronchial asthma is known chronic inflammatory disease. Asthma is categorized into atopic asthma and non-atopic asthma based on absence or presence of atopy which is a positive skin prick test 3 mm or Immunoglobulin E (IgE) specific antibodies that are produced against common allergens. Oxidative stress has a role in pathogenesis of bronchial asthma. Clusterin is a glycoprotein chemokine and has a role in recruitment of inflammatory cells. Aim of the Work: Our aim was to measure serum level of Clusterin in bronchial asthma patients including both (atopic and non-atopic) and to correlate it with the severity of the disease. Materials and Methods: Case control study was done on (96) adult patients diagnosed with bronchial asthma (64 atopic and 32 nonatopic), in addition to (32) sex and age matched healthy controls. Serum Clusterin & IgE levels were measured using enzyme linked immunoassay. Results: Clusterin level was higher in atopic and non atopic patients’ groups when each was compared to control group (p<0.01, respectively). Clusterin was elevated in severe atopic asthma compared to mild and moderate atopic patients (p=0.002 and 0.003, respectively). Clusterin was elevated in moderate non atopic asthma compared to mild non atopic patients (p=0.021). Multi-ROC of IgE and Clusterin at 23 IU/mL (IgE) and 20 ng/mL (Clusterin) showed diagnostic performance efficacy (98.4%) to differentiate between control and non-atopic group Conclusion: Our study revealed that serum Clusterin can be a promising marker in diagnosis of bronchial asthma, and detection of degree of severity. | ||
| Keywords | ||
| Clusterin; Bronchial asthma; Atopy | ||
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