Abdelmageed, W., Al Taher, W. (2014). Preoperative paracetamol infusion reduces sevoflurane consumption during thyroidectomy under general anesthesia with spectral entropy monitoring. test, 30(2), 115-122. doi: 10.1016/j.egja.2013.12.003
Waleed M. Abdelmageed; Waleed M. Al Taher. "Preoperative paracetamol infusion reduces sevoflurane consumption during thyroidectomy under general anesthesia with spectral entropy monitoring". test, 30, 2, 2014, 115-122. doi: 10.1016/j.egja.2013.12.003
Abdelmageed, W., Al Taher, W. (2014). 'Preoperative paracetamol infusion reduces sevoflurane consumption during thyroidectomy under general anesthesia with spectral entropy monitoring', test, 30(2), pp. 115-122. doi: 10.1016/j.egja.2013.12.003
Abdelmageed, W., Al Taher, W. Preoperative paracetamol infusion reduces sevoflurane consumption during thyroidectomy under general anesthesia with spectral entropy monitoring. test, 2014; 30(2): 115-122. doi: 10.1016/j.egja.2013.12.003

Preoperative paracetamol infusion reduces sevoflurane consumption during thyroidectomy under general anesthesia with spectral entropy monitoring

Egyptian Journal of Anaesthesia
Volume 30, Issue 2, April 2014, Pages 115-122    PDF (609.55 K)
DOI: 10.1016/j.egja.2013.12.003
Authors
Waleed M. Abdelmageed; Waleed M. Al Taher
Abstract
Background
Intravenous (IV) paracetamol has a significant opioid-sparing effect. We investigated the effect of paracetamol infusion on sevoflurane consumption during entropy monitored general anesthesia.
Methods
Sixty-two ASA I and II patients undergoing thyroidectomy under general anesthesia were included in a prospective, randomized, double-blind and placebo controlled study. The patients were randomized to receive a slow infusion of either 1 g paracetamol (paracetamol group,  = 31) or saline (control group,  = 31) just before induction of anesthesia. Sevoflurane concentration was titrated to keep the state entropy value between 40 and 50. End-tidal sevoflurane concentration, sevoflurane consumption, recovery characteristics, time to first analgesic request and meperidine consumption during the first 6 postoperative hours were recorded.
Results
The mean ± SD estimated sevoflurane consumption was significantly lower in the paracetamol treated patients (36.2 ± 15 vs 44.9 ± 13.9 ml, in the control group;  = 0.021). Patients receiving paracetamol had a faster post-anesthetic recovery profile (extubation time, time to eye opening to command and time to state name and mention his/her home address) than the other group ( < 0.05). Mean ± SD time to first analgesic request was significantly prolonged in paracetamol group compared to control group (48.4 ± 14.0 vs 40.7 ± 11.5 min, respectively;  = 0.021). Meperidine consumption was higher in control group than in paracetamol group (28.7 ± 10.2 vs 23.1 ± 9.0 mg, respectively;  = 0.025).
Conclusion
Preoperative IV paracetamol infusion improved consumption and emergence from entropy monitored sevoflurane anesthesia with enhancement of the early postoperative analgesia.
Keywords
Paracetamol; Sevoflurane; Spectral entropy
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