Diagnostic Value of Presepsin for Bacterial Infection in Patients with Liver Cirrhosis | ||
| Benha Medical Journal | ||
| Article 15, Volume 42, Issue 4, April 2025, Pages 509-515 PDF (396.07 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2024.333991.2246 | ||
| Authors | ||
| Yehia Sadek Younes1; Hatem Samir Abdel-Raouf Elegily1; Marwa Abdel Monem Ateya2; Hassan El sayed3; Ahmed Abdo Yousif4; Mohammed Salman Soliman* 5 | ||
| 1Professor of Hepatology, Gastroenterology, and Infectious Diseases Faculty of Medicine - Benha University | ||
| 2Assistant professor of Clinical Pathology Faculty of Medicine - Zagazig University | ||
| 3Assistant professor of Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, Egypt | ||
| 4Lecturer of Gastroenterology and Infectious Diseases Department, Ahmed Maher Teaching Hospital, Ministry of Health, Cairo, Egypt | ||
| 5M.B.B. Ch | ||
| Abstract | ||
| Background: Presepsin serum levels can be measured to assess the severity of an infection and to track the clinical effects of therapy interventions. The aim of this work is to evaluate the diagnostic capacity of presepsin serum levels in the early detection of bacterial infections in cirrhotic patients and its usefulness in evaluating response to antibiotic therapy. Methods: This prospective case control study included 52 patients with decompensated liver cirrhosis of various etiologies, with an age of 18 or older and both sexes . Patients were divided into two equal groups: Group A: decompensated cirrhotic patients without bacterial infection and group B: decompensated cirrhotic patients with bacterial infection. Presepsin levels were analyzed by receiving operating characteristic curve to evaluate their ability to predict bacterial infection. Results: Albumin levels were significantly lower in group B than group A (P=0.022). C-reactive protein and Presepsin levels were significantly higher in group B than group A (P | ||
| Keywords | ||
| Diagnosis; Presepsin; Bacterial Infection; Liver Cirrhosis | ||
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