attenuates morphine toxicity in prefrontal cortex in rats | ||
| Egyptian Pharmaceutical Journal | ||
| Volume 18, Issue 3, July 2019, Pages 276-284 PDF (1.12 M) | ||
| DOI: 10.4103/epj.epj_18_19 | ||
| Authors | ||
| Shiva Roshankhah; Cyrus Jalili; Mohammad Reza Salahshoor | ||
| Abstract | ||
| Background Morphine is a major risk factor in the development of functional disorder of several organs. is a vegetable that contains antioxidant ingredients. Objective This study was designed to evaluate the effects of against morphine-induced damage to the prefrontal cortex of rats. Materials and methods In this study, 64 Wistar male rats were randomly assigned to eight groups: sham group, morphine group (20 mg/kg once daily in the first 5 days and double per day in the following 5 days; on the 11th to 20th day, 30 mg/kg, doubles each day), groups (50, 100, and 150 mg/kg), and morphine+ groups (50, 100, and 150 mg/kg). Treatments were administered intraperitoneally daily for 20 days. Ferric reducing/antioxidant power method was applied to determine the total antioxidant capacity. The number of dendritic spines was investigated by Golgi staining. Cresyl violet staining method was used to determine the number of neurons in prefrontal region. Moreover, Griess technique was used to determine serum nitrite oxide level. Results Morphine administration increased significantly nitrite oxide level and total antioxidant capacity and decreased the number of neuronal dendritic spines and neurons compared with the sham group (<0.05). In the and morphine+ groups, in all dosages, the number of neurons and neuronal dendritic spines increased significantly whereas nitrite oxide level and total antioxidant capacity decreased compared with the morphine group (<0.05). Conclusion It seems that administration improves brain’s prefrontal region injury in rats due to morphine. | ||
| Keywords | ||
| morphine; Prefrontal cortex | ||
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