NADA, E., Abdo, R., Mostafa, M., Mohhmed, R. (2018). Efficacy of microneedling with topical vitamin C in treatment of acne scars. test, 22(1), 163-170. doi: 10.21608/smj.2018.40958
ESSAMELDIN ABDELAZIZ NADA; Ramadan Saleh Abdo; Mohammed A. Mostafa; Rasha I. Mohhmed. "Efficacy of microneedling with topical vitamin C in treatment of acne scars". test, 22, 1, 2018, 163-170. doi: 10.21608/smj.2018.40958
NADA, E., Abdo, R., Mostafa, M., Mohhmed, R. (2018). 'Efficacy of microneedling with topical vitamin C in treatment of acne scars', test, 22(1), pp. 163-170. doi: 10.21608/smj.2018.40958
NADA, E., Abdo, R., Mostafa, M., Mohhmed, R. Efficacy of microneedling with topical vitamin C in treatment of acne scars. test, 2018; 22(1): 163-170. doi: 10.21608/smj.2018.40958

Efficacy of microneedling with topical vitamin C in treatment of acne scars

Sohag Medical Journal
Article 18, Volume 22, Issue 1, January 2018, Pages 163-170    PDF (135.26 K)
Document Type: Original Article
DOI: 10.21608/smj.2018.40958
Authors
ESSAMELDIN ABDELAZIZ NADA1; Ramadan Saleh Abdo2; Mohammed A. Mostafa3; Rasha I. Mohhmed3
1DERMATOLOGY, Venereology and Andrology, Faculty of Medicine , sohag university
2Department , of Dermatology, Venereology and Andrology , Faculty of Medicine- , Sohag University
3Department of Dermatology, Faculty of Medicine, Sohag University.
Abstract
Introduction: Acne scars are largely preventable complications of acne. 95% of the scars occur over the face thus impacting the quality of life. Correction of scars is the priority for acne patients. There is no single treatment modality that has been shown to be universally effective. Microneedling is a relatively new minimally invasive procedure used as a collagen induction therapy for skin rejuvenation and facial scars.
Aim of the work: Evaluation of efficacy of microneedling with topical vitamin  C in treatment of acne scars.
Patients and Methods: Ten patients with post acne atrophic facial scars attending the  outpatient clinic of  Dermatology in Sohag University Hospitals between June 2014 to September 2017 were offered  six microneedling sessions plus topical  vit. C (during the session of microneedling and daily topical application in between sessions) microneedling sessions were four weeks apart. They were evaluated monthly and one month after completion of sessions for both efficacy and safety of the procedure.
Results: The mean ± SD of the patients' age in the study population were 28.900 ±5.384yers old nine females and one males with mean acne  scars duration ± SD 11.900±5.506 years, 90%% of patients had psychological distress from their acne scars. At the end of study duration Out of the ten patients 6(60%) achieved one grade reduction in their Goodman and Baron qualitative grading score and 2 (20%) achieved two grade reduction. According to the  quantitative ECCA " Echella d'e valuation Clinique des cicatrices d'acne" score 80% 0f patients achieved reduction in their score  with 27.5%  improvement in the ECCA score.  The mean  ECCA score value of V scar started to decrease earlier than  both U scar, and M scar. 40% of patients had excellent satisfaction and 60% had very good satisfaction. All treated patients, had adverse events of temporary erythema,  edema, bleeding, or a serous ooze resolving with crusting or scabbing following each session of microneedling, bacterial infection not occurred in any of our patients.  
Conclusion: Multiple minimally invasive sessions of skin microneedling with topical vitamin C during sessions and daily application is an effective treatment for post-acne atrophic scars with the advantage of being a relatively risk-free, in-office procedure with minimal patient recovery time.
Keywords
Microneedling; Vitamen C; acne scar
Supplementary Files
References

1.  Admani S, Barrio VR. Evaluation and treatment of acne from infancy to preadolescence. Dermatologic therapy. 2013;26(6):462-6.

2.  Fabbrocini G, Annunziata MC, D'Arco V, De Vita V, Lodi G, Mauriello MC, et al. Acne scars: pathogenesis, classification and treatment. Dermatology research and practice. 2010;2010:893080.

3.  Layton AM, Henderson CA, Cunliffe WJ. A clinical evaluation of acne scarring and its incidence. Clinical and experimental dermatology. 1994;19(4):303-8. 

4.  Cunliffe WJ, Gould DJ. Prevalence of facial acne vulgaris in late adolescence and in adults. British medical journal. 1979;1(6171):1109-10.

5.  Midwood KS, Williams LV, Schwarzbauer JE. Tissue repair and the dynamics of the extracellular matrix. The international journal of biochemistry & cell biology. 2004;36(6):1031-7.

6.  Kravvas G, Veitch D, Al-Niaimi F. The increasing relevance of biofilms in common dermatological conditions. The Journal of dermatological treatment. 2017:1-6.

7.  Fernandes D. Minimally invasive percutaneous collagen induction. Oral and maxillofacial surgery clinics of North America. 2005;17(1):51-63, vi.

8.  Doddaballapur S. Microneedling with dermaroller. Journal of cutaneous and aesthetic surgery. 2009;2(2):110-11 

9.  Bariya SH, Gohel MC, Mehta TA, Sharma OP. Microneedles: an emerging transdermal drug delivery system. The Journal of pharmacy and pharmacology. 2012;64(1):11-29.

10.            Fabbrocini G, Fardella N, Monfrecola A, Proietti I, Innocenzi D. Acne scarring treatment using skin needling. Clinical and experimental dermatology. 2009;34(8):874-9.

11.            Oresajo C, Stephens T, Hino PD, Law RM, Yatskayer M, Foltis P, et al. Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin. Journal of cosmetic dermatology. 2008;7(4):290-7. 

12.            Chen L, Hu JY, Wang SQ. The role of antioxidants in photoprotection: a critical review. Journal of the American Academy of Dermatology. 2012;67(5):1013-24.

13.            Sauermann K, Jaspers S, Koop U, Wenck H. Topically applied vitamin C increases the density of dermal papillae in aged human skin. BMC dermatology. 2004;4(1):13.

14.            Goodman GJ, Baron JA. Postacne scarring: a qualitative global scarring grading system. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al]. 2006;32(12):1458-66. 

15.            Dreno B, Khammari A, Orain N, Noray C, Merial-Kieny C, Mery S, et al. ECCA grading scale: an original validated acne scar grading scale for clinical practice in dermatology. Dermatology. 2007;214(1):46-51.

16.            Leheta T, El Tawdy A, Abdel Hay R, Farid S. Percutaneous collagen induction versus full-concentration trichloroacetic acid in the treatment of atrophic acne scars. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al]. 2011;37(2):207-16. 

17.            Sharad J. Combination of microneedling and glycolic acid peels for the treatment of acne scars in dark skin. Journal of cosmetic dermatology. 2011;10(4):317-23

18.            El-Domyati M, Barakat M, Awad S, Medhat W, El-Fakahany H, Farag H. Microneedling Therapy for Atrophic Acne Scars: An Objective Evaluation. The Journal of clinical and aesthetic dermatology. 2015;8(7):36-42.

19.            Gadkari R, Nayak C. A split-face comparative study to evaluate efficacy of combined subcision and dermaroller against combined subcision and cryoroller in treatment of acne scars. Journal of cosmetic dermatology. 2014;13(1):38-43.

20.            Leheta TM, Abdel Hay RM, El Garem YF. Deep peeling using phenol versus percutaneous collagen induction combined with trichloroacetic acid 20% in atrophic post-acne scars; a randomized controlled trial. The Journal of dermatological treatment. 2014;25(2):130-6.

21.            Majid I. Microneedling therapy in atrophic facial scars: an objective assessment. Journal of cutaneous and aesthetic surgery. 2009;2(1):26-30.

22.            Chawla S. Split Face Comparative Study of Microneedling with PRP Versus Microneedling with Vitamin C in Treating Atrophic Post Acne Scars. Journal of cutaneous and aesthetic surgery. 2014;7(4):209-12.

23.            Dogra S, Yadav S, Sarangal R. Microneedling for acne scars in Asian skin type: an effective low cost treatment modality. Journal of cosmetic dermatology. 2014;13(3):180-7.

24.            Nofal E, Helmy A, Nofal A, Alakad R, Nasr M. Platelet-rich plasma versus CROSS technique with 100% trichloroacetic acid versus combined skin needling and platelet rich plasma in the treatment of atrophic acne scars: a comparative study. Dermatologic surgery: official publication for American Society for Dermatologic Surgery [et al]. 2014;40(8):864-73.

25.            Pinnell SR, Yang H, Omar M, Monteiro-Riviere N, DeBuys HV, Walker LC, et al. Topical L-ascorbic acid: percutaneous absorption studies. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al]. 2001;27(2):137-42.

26.            Matsuda S, Shibayama H, Hisama M, Ohtsuki M, Iwaki M. Inhibitory effects of a novel ascorbic derivative, disodium isostearyl 2-O-L-ascorbyl phosphate on melanogenesis. Chemical & pharmaceutical bulletin. 2008;56(3):292-7.

27.            Fabbrocini G, De Vita V, Di Costanzo L, Pastore F, Mauriello MC, Ambra M, et al. Skin needling in the treatment of the aging neck. Skinmed. 2011;9(6):347-51.

28.            Alam M, Han S, Pongprutthipan M, Disphanurat W, Kakar R, Nodzenski M, et al. Efficacy of a needling device for the treatment of acne scars: a randomized clinical trial. JAMA dermatology. 2014;150(8):844-9.

 

 

Statistics
Article View: 1,301
PDF Download: 935