The relationship between Adiponectin and Serum Oxidative Stress factors in Parkinson's Disease | ||
| Zagazig University Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 18 February 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2025.357937.3827 | ||
| Authors | ||
| mohamed hamdy ismail* 1; hossam refat1; ahmad sallam2; Nancy Abdelhamid Mohammad1 | ||
| 1neurology department, faculty of medicine , zagazig university | ||
| 2clinicalpathology department, faculty of medicine , zagazig university | ||
| Abstract | ||
| Abstract Background: Parkinson's disease [PD] is a common neurodegenerative disease. Oxidatant stress factors are a main cause in the pathogenesis of PD. Our study aimed to estimate the relations between serum levels of vitamin C, ferritin, transferrin, Nitrite Oxide [NOx] and Adiponectin in correlation with parkinsonian severity. Methods: a case control study done on27 PD patients and 27 healthy subjects, measuring serum vitamin C, ferritin, transferrin, Nitrite Oxide [NOx] and Adiponectin levels with UNIFIED PARKINSON'S DISEASE RATING SCALE (UPDRS) was done to detect parkinsonian severity in the patients. Results: there is a significant difference between the two studied groups regarding age, NOx, vitamin C, and ferritin level. There is also significant difference between the patients and control groups regarding Adiponectin level [it is significantly higher among case group]. The cutoff point of serum Adiponectin in diagnosis of Parkinsonism is ≥12.115 μg/mL and the area under curve was 0.866, sensitivity 92.6%, specificity 81.5%, the value of positive prediction was 83.3%, negative predictive was 91.7% and overall accurateness was 87%.there were a positive correlation between Adiponectin and NOx, UPDRS and ferritin among case group. Conclusion: Serum levels of vit C, ferritin ,NOx and Adiponectin are significantly higher in patients with PD. In addition, it can be suggested that to have a role in progression of PD. More researches are needed on more patients and different ethnics to afford more data about the disease severity and the outcome. | ||
| Keywords | ||
| Trace elements; Vit C; Ferritin; Nitric oxide, Adiponectin | ||
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