Forty and Beyond: A SWOT Analysis of PGT-A in the Context of Aging and Fertility

Maghraby, Hassan; Ali Saleh, Hisham; Abo Ali, Ashraf; Sharaf, Hayat; Shehata, Amr; Elmahdy, Mohamed; Adel, Nehal; Hassan, Heba; Gaafar, Sherif

doi:10.21608/jrme.2025.362026.1029

	Forty and Beyond: A SWOT Analysis of PGT-A in the Context of Aging and Fertility
Journal of Reproductive Medicine and Embryology
Article 9, Volume 1, Issue 4, February 2025, Pages 262-275 PDF (414.78 K)
Document Type: Original Article
DOI: 10.21608/jrme.2025.362026.1029
Authors
Hassan Maghraby^* ¹^{, 2}; Hisham Ali Saleh¹^{, 2}^{, 3}; Ashraf Abo Ali²^{, 4}; Hayat Sharaf¹^{, 2}^{, 5}; Amr Shehata²^{, 6}; Mohamed Elmahdy¹^{, 2}; Nehal Adel²^{, 4}; Heba Hassan⁷^{, 2}; Sherif Gaafar¹^{, 2}^{, 4}
¹Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt.
²Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt.
³Agial Fertility Center, Alexandria, Egypt.
⁴Madina Fertility Center, Madina Women's Hospital, Alexandria, Egypt.
⁵Obstetrics and Gynecology Department, Faculty of Medicine, Hodeidah University, Al-Hodeidah, Yemen.
⁶Obstetrics and Gynecology Department, Faculty of Medicine, Aswan University, Egypt.
⁷Dar Alteb Infertility Center, Alexandria, Egypt.
Abstract
Preimplantation genetic testing for aneuploidy (PGT-A) is widely used in in vitro fertilization (IVF) to detect chromosomal abnormalities in embryos. This testing employs various platforms—including quantitative PCR, array comparative genomic hybridization (aCGH), and next-generation sequencing (NGS)—each with its own advantages and limitations. The goal of these technologies is to enhance clinical outcomes, reduce the time to pregnancy, and ultimately improve the likelihood of delivering a healthy baby. Additionally, emerging approaches such as non-invasive PGT using spent culture medium show promise for future application. However, it is important to recognize that PGT-A functions as a screening tool rather than a definitive indicator of the chromosomal status of embryos or fetuses. While advocates claim that PGT-A enhances IVF outcomes, critics argue that it lacks adequate clinical validation and may reduce live birth rates due to its high false-positive rate.This article employs a SWOT analysis to evaluate the advantages, challenges, opportunities, and risks of PGT-A in women of advanced maternal age.
Keywords
PGT-A; SWOT; Strength; Weakness; Opportunity

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