Assessment of Kidney Status in Cardiac Children Treated with Angiotensin Converting Enzyme Inhibitors | ||
| Zagazig University Medical Journal | ||
| Article 7, Volume 26, Issue 3, May 2020, Pages 414-422 PDF (948.57 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2019.14715.1329 | ||
| Authors | ||
| Doaa Mohammed Youssef* 1; Ezzat Kamel2; azza khalil3; tarek ayyat4 | ||
| 1pediatrics, faculty of medicine, zagazig university Postal Code: 44519 info@zu.edu.eg : E-MailAddress:Zagazig - Zagazig UniversitySharkia - Egypt | ||
| 2pediatric nephrology unit , zagazig university, Egypt Postal Code: 44519 info@zu.edu.eg : E-MailAddress:Zagazig - Zagazig UniversitySharkia - Egypt | ||
| 3pediatric department Postal Code: 44519 info@zu.edu.eg : E-MailAddress:Zagazig - Zagazig UniversitySharkia - Egypt | ||
| 4pedaitric departemnt Postal Code: 44519 info@zu.edu.eg : E-MailAddress:Zagazig - Zagazig UniversitySharkia - Egypt | ||
| Abstract | ||
| Background: Angiotensin Converting Enzyme Inhibitors (ACEIs) are commonly used to treat many cases especially chronic heart failure and there is different data about kidney affection in those patients, we aimed in this study to evaluate the kidney status in patients using this medication weather on chronic bases or recently added. Patients and methods: We studied 50 cardiac children 15 of them with old treatment with ACEIs group A, 15 of them with new treatment with ACEIs group B and 20 of them not use ACEIs as a control group as group C, all patients were subjected to detailed history taking including demographic data, Glomerular filtration rate calculated For children by modified Schwartz method in addition to Routine test of kidney function. Results: There was statistically significant higher creatinine level and lower eGFR in group A and B than control group, there was 40% of patients on old ACEIs treatment suffered from metabolic acidosis and increased creatinine level in blood compared to (10% and 20% among group B, 5% and 0% among group C respectively), while 50% of group A suffered of hyperkalemia and decreased GFR versus 20% among group B and 5% among group C respectively, and the difference between groups was statistically significant. There was a statistically significant negative correlation between duration using ACEIs and GFR and urine output, Conclusion: We concluded that there is high risk of renal impairment in cardiac children treated with ACEIs and this risk is higher with increasing duration of therapy with these drugs | ||
| Keywords | ||
| ACEIs; Pediatric; Heart failure; renal | ||
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