Combination of Fibrotic Markers accurately predict liver fibrosis in Hepatitis C Patients | ||
| Biochemistry Letters | ||
| Article 15, Volume 14, Issue 1, 2018, Pages 180-186 PDF (602.45 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/blj.2018.47619 | ||
| Authors | ||
| Faten Zahran Mohamed1; Ibrahim El-Sayed M. El-Deen2; Dina Mohamed Mohamed Ismail2 | ||
| 1Chemistry Department , Faculty of Science ,ZagazigUniversity ,Egypt | ||
| 2Chemistry Department, Faculty of Science, Port Said University, Egypt | ||
| Abstract | ||
| Liver biopsy is invasive and prone to complications but it stills the gold standard for assessing hepatitis C virus (HCV)-related fibrosis. This study was designed to study non-invasive methods for the assessment of liver fibrosis. Our aim was to validate and compare the performance of MMP-8, upA in addition to GAL-3 as simple blood markers for different stages of liver fibrosis in HCV patients. The study was carried out on 90 individuals divided into the following groups: group 1: normal control, group 2: F1 = portal fibrosis without septa, group 3: F2 = few septa, group 4: F3 = numerous septa without cirrhosis and group 5: F4 = cirrhosis. Our results showed a positive correlation between MMP-8, upA and GAL-3 level and degree of liver fibrosis. We can conclude that, using of MMP-8, upA in addition to GAL-3 as simple biochemical markers for the assessment of hepatic fibrosis as alternative to liver biopsy. | ||
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