Elsawy, M., El Abd, M., Elsheikh, S., Abdelraouf, M., Basyouny, A., Ghanem, Y. (2007). GHRELIN IN POLYCYSTIC OVARIAN SYNDROME WITH AND WITHOUT DIABETES MELLITUS IN EGYPTIAN POPULATION. test, 11(1), 23-30. doi: 10.21608/egyfs.2007.4951
Mohamed Elsawy; Mohamed El Abd; Samir Elsheikh; Mohamed Abdelraouf; Ahmed Basyouny; Yehia Ghanem. "GHRELIN IN POLYCYSTIC OVARIAN SYNDROME WITH AND WITHOUT DIABETES MELLITUS IN EGYPTIAN POPULATION". test, 11, 1, 2007, 23-30. doi: 10.21608/egyfs.2007.4951
Elsawy, M., El Abd, M., Elsheikh, S., Abdelraouf, M., Basyouny, A., Ghanem, Y. (2007). 'GHRELIN IN POLYCYSTIC OVARIAN SYNDROME WITH AND WITHOUT DIABETES MELLITUS IN EGYPTIAN POPULATION', test, 11(1), pp. 23-30. doi: 10.21608/egyfs.2007.4951
Elsawy, M., El Abd, M., Elsheikh, S., Abdelraouf, M., Basyouny, A., Ghanem, Y. GHRELIN IN POLYCYSTIC OVARIAN SYNDROME WITH AND WITHOUT DIABETES MELLITUS IN EGYPTIAN POPULATION. test, 2007; 11(1): 23-30. doi: 10.21608/egyfs.2007.4951

GHRELIN IN POLYCYSTIC OVARIAN SYNDROME WITH AND WITHOUT DIABETES MELLITUS IN EGYPTIAN POPULATION

The Egyptian Journal of Fertility and Sterility
Article 4, Volume 11, Issue 1, January 2007, Pages 23-30    PDF (2.53 M)
Document Type: Original Article
DOI: 10.21608/egyfs.2007.4951
Authors
Mohamed Elsawy1; Mohamed El Abd2; Samir Elsheikh3; Mohamed Abdelraouf4; Ahmed Basyouny3; Yehia Ghanem3
1Department of Clinical Pathology. Alexandria University
2Department of Obstetrics and Gynecology, Alexandria University
3Department of Internal Medicine, Alexandria University
4Department of Internal Medicine, Menoufeya University
Abstract
Background and aim: Ghrelin is a 28 amino acid peplide, which is primarily produced by the stomach. Ghrclin i.s a strong sccrelagogue of growth hormone (GH).The polycyslic ovary syndrome (PCOS) is Iradilionaliy characterized by chronic anovulalion, funclional hypcrandrogenism. Obesity of the central type and Insulin Resistance (IR) arc highly associated with the syndrome, predisposing women with PCOS to the development of glucose intolerance and. ultimately, type 2 diabetes mcllitus. In the current study, we investigated fasting plasma ghrelin levels in a group of patients with PCOS, with and without type 2 DM, and compared with an age matched control group. Results: Fasting plasma ghrclin was significantly lower in PCOS patients than in control groups.
Conclusion: Fasting plasma ghrelin levels were significantly lower in PCOS groups as compared to the control group, Decreased plasma ghrclin levels correlated significantly with Insulin resistance in the patients groups.
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