Residues of Diclofenac Sodium in Rabbit Tissues | ||
| Zagazig Veterinary Journal | ||
| Article 7, Volume 47, Issue 3, September 2019, Pages 298-305 PDF (623.85 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zvjz.2019.13635.1048 | ||
| Authors | ||
| Gamal Shams1; nagah mohamed1; elham mobarez2; sara abd el wahab* 3 | ||
| 1Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt | ||
| 2Animal Health Research Institute, Dokki, Giza, Egypt | ||
| 3Animal Health Research Institute, Zagazig, Egypt | ||
| Abstract | ||
| The current study aimed to determine residues of diclofenac in different rabbit tissues (liver, muscles, kidneys, spleen, heart , lungs) and serum following intramuscular injection of diclofenac. Tissues were extracted and diclofenac residues were assayed using high-performance liquid chromatography (HPLC). A total of twenty healthy male New Zealand White rabbits were classified into two groups; the first group (n=15) was injected with diclofenac for four successive days at dose 1.5mg/kg twice daily , while the second group (n=5) untreated (control). and then samples were collected on the 1st day , 3rd day, 5thday and 7th day. Diclofenac remained within the detectable limit till the 3rd day in most tested tissues, while in muscle and kidney remained till the 5th day following the last dose of drug administration . Therefore, It can be concluded that rabbit muscles and kidney could be consumed safely after the 5th day post treatment with that dose, while, rabbit liver could be consumed safely after the 3rd day post treatment with that dose without any hazards on consumers according to established recommended MRL. | ||
| Keywords | ||
| residues; Diclofenac; Rabbits; HPLC | ||
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