AbouLaila, M., Abdelaziz, A., Rizk, M., Mady, R., Yokoyama, N., Igarashi, I. (2019). Evaluation of the in vitro and in vivo inhibitory effects of quercetin on the growth of Babesia and Theileria parasites. test, 2(1), 23-27. doi: 10.21608/djvs.2019.53159
Mahmoud AbouLaila; Amer Abdelaziz; Mohamed Rizk; Rehab Mady; Naoaki Yokoyama; Ikuo Igarashi. "Evaluation of the in vitro and in vivo inhibitory effects of quercetin on the growth of Babesia and Theileria parasites". test, 2, 1, 2019, 23-27. doi: 10.21608/djvs.2019.53159
AbouLaila, M., Abdelaziz, A., Rizk, M., Mady, R., Yokoyama, N., Igarashi, I. (2019). 'Evaluation of the in vitro and in vivo inhibitory effects of quercetin on the growth of Babesia and Theileria parasites', test, 2(1), pp. 23-27. doi: 10.21608/djvs.2019.53159
AbouLaila, M., Abdelaziz, A., Rizk, M., Mady, R., Yokoyama, N., Igarashi, I. Evaluation of the in vitro and in vivo inhibitory effects of quercetin on the growth of Babesia and Theileria parasites. test, 2019; 2(1): 23-27. doi: 10.21608/djvs.2019.53159

Evaluation of the in vitro and in vivo inhibitory effects of quercetin on the growth of Babesia and Theileria parasites

Damanhour Journal of Veterinary Sciences
Article 5, Volume 2, Issue 1, 2019, Pages 23-27    PDF (480.42 K)
Document Type: Original Article
DOI: 10.21608/djvs.2019.53159
Authors
Mahmoud AbouLaila* 1; Amer Abdelaziz2; Mohamed Rizk3; Rehab Mady4; Naoaki Yokoyama5; Ikuo Igarashi5
1Department of Parasitology, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, El-Behera, Egypt
2Department of Parasitology, Faculty of Veterinary Medicine, Sohag University, Sohag82524, Egypt
3Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt
4Department of Pharmacology, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, El-Behera, Egypt
5Department of Disease Control, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido
Abstract
Quercetin has antioxidant, anti-inflammatory, antitrypanosomal, and antimalarial activities. The hindering properties of quercetin were appraised for three Babesia species and Theileria equi in vitro and against Babesia microti in mice. Quercetin exhibited substantial growth restraint for Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi with IC50 values of 8, 7, 5, and 4 nM, respectively. T. equi growth was suppressed at 50 μM concentration. Parasite regrowth was repressed in the consequent viability test at 100 μM for Babesia bovis and Babesia bigemina and 50 μM for Babesia caballi and Theileria equi. Quercetin at a dose rate of 14.5 mg/kg raised a 77.5 % reticence of Babesia microti progression in BALB/c mice. Quercetin might be of value as a treatment in babesiosis and theileriosis.
Keywords
Quercetin; Babesia; Theileria equi; in Vitro; in vivo
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