Evaluation of Effect of Low-Density Lipoprotein Levels on the Measurement of Hepatitis C Viral Load in Chronic Hepatitis C Patients | ||
| Suez Canal University Medical Journal | ||
| Article 2, Volume 16, Issue 2, October 2013, Pages 87-93 PDF (826.89 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scumj.2013.54219 | ||
| Authors | ||
| Basma B Hasan1; Essam M Abdalla1; Abdul Malek M Nasar1; Nahed Youssef* 1; Ahmed A El Hawary2 | ||
| 1Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt | ||
| 2Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt | ||
| Abstract | ||
| Background: Low density lipoprotein receptor (LDLR) has been proposed as a candidate receptor for hepatitis C virus (HCV). Free beta-lipoproteins in a human serum may regulate the rate of hepatocyte infection by competing with the virus. Therefore, serum HCV levels should be regulated by rise and fall of serum beta-lipoproteins since the infection rate of virions influences HCV replication in hepatocytes and release of virions by hepatocytes. Aim: To evaluate effect of low-density lipoprotein levels on the measurement of hepatitis C viral load in chronic hepatitis C patients and estimate the levels of viral load of hepatitis C in relation to variation of the corresponding low-density lipoprotein levels in chronic hepatitis C patients and their relations to each other. Subjects and Methods: 30 HCV hyperlipidemic patients were subjected to clinical evaluation and laboratory investigations included follow up by repeated measurements of LDL level, AST, ALT, and Albumin for patient selection. Results: There was an inverse statistically significant correlation (r = -0.388, p=0.034) between the HCV RNA absolute viral load differences and LDL level absolute differences (the lower the LDL differences, the higher the HCV RNA differences). Also, there was an inverse statistically significant correlation (r=-0.42, p=0.021) between HCV RNA absolute differences and LDL level percent differences (the higher the LDL percent differences, the lower the HCV RNA absolute differences).The predictive variables for HCV RNA viral load level differences were LDL level differences and LDL percent differences whereas AST, ALT, and Albumin differences were not. Conclusion: Low-density lipoprotein levels have an effect on the measurement of hepatitis C viral load in chronic hepatitis C patients. Therefore, this must be taken in consideration when chronic hepatitis C patients have a history of dyslipidemia and perform a HCV RNA viral load by PCR. | ||
| Keywords | ||
| HCV; LDLR; LDL-cholesterol | ||
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