SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW SUBSTITUTED DIHYDROPYRIMIDINE DERIVATIVES | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 5, Volume 34, Issue 1, 2011, Pages 37-52 PDF (348.56 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2012.63216 | ||
| Authors | ||
| Mostafa A. Hussein* 1; Samia G. Abdel Moty1; Salah A. Abdel Aziz2; Mahrous A. Abou- Salim3 | ||
| 1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Egypt | ||
| 2Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Al Azhar University, Assiut, Egypt | ||
| 3Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al Azhar University, Assiut, Egypt | ||
| Abstract | ||
| A new series of ethyl 6-methyl-4-(substituted)phenyl-2-(substituted)-phenacyl-thio-1,4- dihydropyrimidine-5-carboxylate (2a-x) was prepared by reaction of ethyl 1,2,3,4-tetrahydro-6- methyl-4-(substituted)phenyl-2-thioxopyrimidine-5-carboxy-late 1(a–d) with phenacyl bromides. Compounds 1(a–d) were synthesized using the principle of Bignelli condensation by one pot reaction of the appropriate araldehyde, ethyl acetoacetate and thiourea in acidic medium. Confirmation of the chemical structure of the synthesized compounds (2a-x) was substintiated by different spectral data IR, 1H-NMR, MS in addition to their microanalyses. The newly synthesized compounds were evaluated for their antimicrobial activities. The antibacterial and antifungal testing identified compounds 2b, 2e, 2k, 2l, 2m, 2n, 2o, 2p, 2q, 2r and 2x as the most effective agents in comparison to Chloramphenicol and Clotrimazole as reference antibacterial and antifungal drugs respectively. | ||
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