Sayed, H., Mohamed, M., Darwish, F., Mohamed, A. (2006). PHYTOCHEMICAL AND BIOLOGICAL INVESTIGATIONS OF FLACOURTIA CATAPHRACTA ROXB. CULTIVATED IN EGYPT. test, 29(2), 371-387. doi: 10.21608/bfsa.2006.65215
Hanaa M. Sayed; Mahmoud H. Mohamed; Faten M. Darwish; Ahmed M. Mohamed. "PHYTOCHEMICAL AND BIOLOGICAL INVESTIGATIONS OF FLACOURTIA CATAPHRACTA ROXB. CULTIVATED IN EGYPT". test, 29, 2, 2006, 371-387. doi: 10.21608/bfsa.2006.65215
Sayed, H., Mohamed, M., Darwish, F., Mohamed, A. (2006). 'PHYTOCHEMICAL AND BIOLOGICAL INVESTIGATIONS OF FLACOURTIA CATAPHRACTA ROXB. CULTIVATED IN EGYPT', test, 29(2), pp. 371-387. doi: 10.21608/bfsa.2006.65215
Sayed, H., Mohamed, M., Darwish, F., Mohamed, A. PHYTOCHEMICAL AND BIOLOGICAL INVESTIGATIONS OF FLACOURTIA CATAPHRACTA ROXB. CULTIVATED IN EGYPT. test, 2006; 29(2): 371-387. doi: 10.21608/bfsa.2006.65215

PHYTOCHEMICAL AND BIOLOGICAL INVESTIGATIONS OF FLACOURTIA CATAPHRACTA ROXB. CULTIVATED IN EGYPT

Bulletin of Pharmaceutical Sciences Assiut University
Article 9, Volume 29, Issue 2, December 2006, Pages 371-387    PDF (346.27 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2006.65215
Authors
Hanaa M. Sayed1; Mahmoud H. Mohamed2; Faten M. Darwish1; Ahmed M. Mohamed2
1Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt
Abstract
The concentrated 70% ethanolic extracts of the air-dried powdered leaves and stem bark of Flacourtia cataphracta were subjected separately to solvent fractionation by partitioning using n-hexane, chloroform and ethyl acetate respectively. Each concentrated fraction was subjected to TLC followed by isolation, purification and identification of the available constituents. Fourteen compounds were isolated and identified by different spectral tools (UV, IR, 1H-NMR, 13C-NMR, MS) and comparison with corresponding literature data.  -amyrin (1),  -amyrin (2), and a mixture of  -sitosterol and stigmasterol (3) were isolated from nhexane fraction of both leaves and stem bark. 2-Oxo-18benzolyloxy-13(16), 14-tetrahydrocleroda-3-ene (4), 3 -acetoxyD:A friedo oleanan-27,16  -lactone (5), 4,4'-dihydroxychalcone (6), apigenin (7) and kampferol (8) were isolated from chloroform fraction of the stem bark.  -Sitosterol-3-O -D-glucoside (9), 5-Ocaffeoylquinic acid (10) were isolated from the ethyl acetate fraction of the leaves in addition to vanillin (11), benzoic acid (12), protocatechuic acid (13) and flacourtin (14) from the ethyl acetate fraction of the stem bark. The different leaf extracts were subjected to biological study which revealed that n-hexane, ethyl acetate and methanol fractions of Flacourtia cataphracta Roxb. are safe to be used as antidiarrheal, anti-inflammatory and antipyretic drug.
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