Helal, E., Zaki, D., Abdelaziz, M., Zakaria, A. (2019). Effect of Both Bisphenol - A and Liquorice on Some Sexual Hormones in Male Albino Rats and Illustration of the Effect of Stem Cell Enhancer on Their Actions. test, 77(6), 5922-5929. doi: 10.21608/ejhm.2019.65257
Eman G.E. Helal; Dina Alsayed Zaki; Mohamed A. Abdelaziz; Abeer Zakaria. "Effect of Both Bisphenol - A and Liquorice on Some Sexual Hormones in Male Albino Rats and Illustration of the Effect of Stem Cell Enhancer on Their Actions". test, 77, 6, 2019, 5922-5929. doi: 10.21608/ejhm.2019.65257
Helal, E., Zaki, D., Abdelaziz, M., Zakaria, A. (2019). 'Effect of Both Bisphenol - A and Liquorice on Some Sexual Hormones in Male Albino Rats and Illustration of the Effect of Stem Cell Enhancer on Their Actions', test, 77(6), pp. 5922-5929. doi: 10.21608/ejhm.2019.65257
Helal, E., Zaki, D., Abdelaziz, M., Zakaria, A. Effect of Both Bisphenol - A and Liquorice on Some Sexual Hormones in Male Albino Rats and Illustration of the Effect of Stem Cell Enhancer on Their Actions. test, 2019; 77(6): 5922-5929. doi: 10.21608/ejhm.2019.65257

Effect of Both Bisphenol - A and Liquorice on Some Sexual Hormones in Male Albino Rats and Illustration of the Effect of Stem Cell Enhancer on Their Actions

The Egyptian Journal of Hospital Medicine
Article 22, Volume 77, Issue 6, October 2019, Pages 5922-5929    PDF (217.99 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.65257
Authors
Eman G.E. Helal* 1; Dina Alsayed Zaki2; Mohamed A. Abdelaziz3; Abeer Zakaria1
1Zoology Department, Faculty of Science (Girls), Al-Azhar University-Cairo
2Baterij Medical College-KSA
3Physiology Department, Faculty of Medicine, Al-Azhar University-cairo.
Abstract
Background: Xenoestrogens are a type of xenohormone that imitates estrogen. They can be either synthetic or natural chemical compounds. Synthetic xenoestrogens include some widely used industrial compounds, such as PCBs, bisphenol A (BPA) and phthalates. "Dietary estrogen" is also called phytoestrogen, which is a plantderived xenoestrogen not generated within the endocrine system, but consumed by eating phytoestrogenic plants. Stem cell enhancer (SCE) (StemEnhance®) is a novel mobilizer of bone marrow adult stem cells that was shown to increase the number of circulating stem cells. Objectives: The aim of the current work was to clarify the effect of both BPA and liquorice together on some sexual hormones and illustration of the effect of stem cell enhancer on their actions. Materials and methods: Thirty male albino rats were used and were divided into three groups: Group I: control (untreated group), group II: rats treated with BPA and liquorice and group III: rats treated with BPA and anise oil in addition to stem cell enhancer. Blood samples were collected for different biochemical investigations. Results: There was a highly significant increase (p < 0.01) in the level of ALT and AST activities, urea, creatinine, FSH, prolactin, total cholesterol, triglycerides, LDL-C, VLDL, LDL/HDL and TC/HDL. While, there was highly significant decrease (p < 0.01) in HDL-C, total protein, albumin, globulin, testosterone and LH. These results turned back to the normal values after receiving the SCE as compared to normal group. Conclusion: It could be concluded that phytoestrogen and xenoeostrogen have undesirable effects and it is recommended to minimize the utilization of these compounds to protect people from its hazardous effects.
Keywords
BPA; Liquorice; Stem Cell Enhancer; Hormonal assay; biochemical parameters
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