SPECTROPHOTOMETRIC DETERMINATION OF FAMOTIDINE USING P-CBLORANILIC ACID | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 8, Volume 23, Issue 2, December 2000, Pages 156-163 PDF (1.63 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2000.66402 | ||
| Author | ||
| H. A. Mohamed | ||
| Department of Pharmaceutical Analytical Chemistry, Assiut University, Egypt | ||
| Abstract | ||
| Simple and accurate spectrophotometric method/or the analysis of famotidine have been presented. The method was based on the interaction of famotidine and p-chloranillc acid (pCA) in acetonitrile to give a stable and purple colored product measured at 521 nm. The first derivative value of the interaction product with p-CA was also measured at 323 nm. The optimum experimental parameters have been worked out. Beer's law was obeyed from 25 to 240 µglml and from 2 to 30 µg/ml for the direct absorbance and first derivative measurements respectively. The method enabled the assay of famotidine in its tablets. The derivative method was applied for the determination of famotidine in tablets and spiked urine. Recovery was quantitative and relative standard deviation did not exceed 2 %. | ||
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