Tarrad, N., Hassan, S., Madkour, G., Shaker, O. (2019). PROGNOSTIC VALUE OF SERUM HIGH SENSITIVITY C-REACTIVE PROTEIN IN PATIENTS WITH PERIODONTITIS AND DIABETES MELLITUS TYPE 2 AFTER NON-SURGICAL PERIODONTAL TREATMENT. test, 65(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), 1411-1419. doi: 10.21608/edj.2019.72566
Nayroz Abdelfattah Tarrad; Sandy Shaaban Hassan; Gihane Gharib Madkour; Olfat Gamel Shaker. "PROGNOSTIC VALUE OF SERUM HIGH SENSITIVITY C-REACTIVE PROTEIN IN PATIENTS WITH PERIODONTITIS AND DIABETES MELLITUS TYPE 2 AFTER NON-SURGICAL PERIODONTAL TREATMENT". test, 65, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), 2019, 1411-1419. doi: 10.21608/edj.2019.72566
Tarrad, N., Hassan, S., Madkour, G., Shaker, O. (2019). 'PROGNOSTIC VALUE OF SERUM HIGH SENSITIVITY C-REACTIVE PROTEIN IN PATIENTS WITH PERIODONTITIS AND DIABETES MELLITUS TYPE 2 AFTER NON-SURGICAL PERIODONTAL TREATMENT', test, 65(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)), pp. 1411-1419. doi: 10.21608/edj.2019.72566
Tarrad, N., Hassan, S., Madkour, G., Shaker, O. PROGNOSTIC VALUE OF SERUM HIGH SENSITIVITY C-REACTIVE PROTEIN IN PATIENTS WITH PERIODONTITIS AND DIABETES MELLITUS TYPE 2 AFTER NON-SURGICAL PERIODONTAL TREATMENT. test, 2019; 65(Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 1411-1419. doi: 10.21608/edj.2019.72566

PROGNOSTIC VALUE OF SERUM HIGH SENSITIVITY C-REACTIVE PROTEIN IN PATIENTS WITH PERIODONTITIS AND DIABETES MELLITUS TYPE 2 AFTER NON-SURGICAL PERIODONTAL TREATMENT

Egyptian Dental Journal
Article 27, Volume 65, Issue 2 - April (Oral Medicine, X-Ray, Oral Biology & Oral Pathology), April 2019, Pages 1411-1419    PDF (444.47 K)
Document Type: Original Article
DOI: 10.21608/edj.2019.72566
Authors
Nayroz Abdelfattah Tarrad1; Sandy Shaaban Hassan1; Gihane Gharib Madkour2; Olfat Gamel Shaker3
1Lecturer, Department of Oral diagnosis, Oral Medicine, and Periodontology, Faculty of Dentistry, Fayoum University, Egypt
2Associate Professor, Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, Egypt
3Professor, Department of Biochemistry, Faculty of Medicine, Cairo University, Egypt
Abstract
Objectives: Our aim in the current study is to evaluate the level of high sensitivity C-reactive protein in serum of patients with periodontitis and type 2 diabetes before and after non-surgical periodontal treatment.
Subjects and methods: 60 individuals in total with stage II grade A generalized periodontitis (n=20) and stage II grade B generalized periodontitis with type 2 diabetes (n=20) along with healthy control subjects (n=20) were enrolled in this study. Serum samples from all participants were obtained. Two serum samples, before & after non-surgical periodontal treatment, were gathered from patients with periodontitis and periodontitis with type 2 diabetes. Only one serum sample was collected from healthy controls. Enzyme linked immunosorbent assay technique (ELISA) was used to measure serum levels of high sensitivity C-reactive protein (hs-CRP).
Results: The highest concentration of serum hs-CRP was detected in patients with periodontitis & type 2 diabetes. This is followed by periodontitis group and then controls subjects. A statistical significant reduction in the hs-CRP serum levels after non-surgical periodontal treatment was detected in periodontitis with diabetes group while the periodontitis group showed similar reduction but without statistical significance. High diagnostic accuracy of serum hs-CRP was revealed by the Receiver Operating Characteristic (ROC) curve analysis, especially when comparing periodontitis patients, with or without diabetes, with the control.
Conclusions: Serum hs-CRP could be utilized as a prognostic marker in patients with periodontitis and type 2 diabetes.
Keywords
Periodontitis; Type 2 Diabetes; serum high sensitivity C-reactive protein; non-surgical periodontal therapy
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