El-Kommos, M., Youssef, A. (1987). COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS. 4- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND F, R AND X PARAMETERS OF RING SUBSTITUENTS. test, 10(2), 21-33. doi: 10.21608/bfsa.1987.74393
M. E. El-Kommos; A. F. Youssef. "COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS. 4- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND F, R AND X PARAMETERS OF RING SUBSTITUENTS". test, 10, 2, 1987, 21-33. doi: 10.21608/bfsa.1987.74393
El-Kommos, M., Youssef, A. (1987). 'COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS. 4- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND F, R AND X PARAMETERS OF RING SUBSTITUENTS', test, 10(2), pp. 21-33. doi: 10.21608/bfsa.1987.74393
El-Kommos, M., Youssef, A. COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS. 4- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND F, R AND X PARAMETERS OF RING SUBSTITUENTS. test, 1987; 10(2): 21-33. doi: 10.21608/bfsa.1987.74393

COLORIMETRIC DETERMINATION OF PHENOTHIAZINE DRUGS. 4- CORRELATION BETWEEN MOLAR ABSORPTIVITY AND F, R AND X PARAMETERS OF RING SUBSTITUENTS

Bulletin of Pharmaceutical Sciences Assiut University
Article 2, Volume 10, Issue 2, December 1987, Pages 21-33    PDF (336.01 K)
Document Type: Original Article
DOI: 10.21608/bfsa.1987.74393
Authors
M. E. El-Kommos; A. F. Youssef
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt
Abstract
Colorimetric determination of phenothiazines with NBS in strong sulfuric acid solution has been previously reported (6, 7). Correlation of log emax with  and 2cv parameters of C-2 and N-10 substituents is highly significant only on absence of vulnerable groups at C-2 position. Log emax of four compounds with the same N-10 side chain was correlated with Á parameters of C-2 substituents irrespective of their vulnerability to the reagents. Correlation equations were used to predict the electronic parameters Á, and sp of –SO2N(CH3)2 from the spectrophotometric reaction model. 
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