Rice Bran Oil Ameliorates Hepatic Insulin Resistance in Fructose Fed-Rats | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 5, Volume 71, Issue 4, April 2018, Pages 2885-2891 PDF (685.75 K) | ||
| Document Type: Original Article | ||
| Author | ||
| Sohaier A. Abd Elbast1, Mona A. Mohamed2*, Mervat A. Ahmed1, Nehad A. Ali1* | ||
| 1Zoology Department, Faculty of Science, Al-Azhar University, Cairo, 2Biochemistry Division, Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| Background: Insulin resistance is a pathological condition characterized by inadequate peripheral tissue metabolic response to circulating insulin. High dietary fructose causes insulin resistance syndrome, primarily due to simultaneous induction of genes involved in glucose, lipid and mitochondrial oxidative metabolism. Rice bran oil (RBO) is a rich source of antioxidants which contribute to higher oxidative stability and longer shelf life than other edible oils. Aim of the work: The current study investigated the effects of the daily intake of RBO on insulin resistant rat liver, as a central organ in carbohydrate metabolism. Materials and methods: Rats were allocated in 5 groups. Animals in groups 1 and 2 received standard diet and standard diet containing RBO, respectively. Group 3: animals fed high fructose diet (HFD), which was categorized into: rats fed HFD either for one month (HFD1) or for 2 months (HFD2). Group 4, rats were fed HFD containing RBO for one month (HFD1+RBO), while rats in group 5 were fed HFD for 30 days then RBO was added to the diet for another 30 days (HFD2+RBO). Results and conclusion: addition of RBO to this model improved insulin sensitivity in liver. | ||
| Keywords | ||
| Insulin Resistance; rice bran oil; glycogen | ||
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