Elkady, M., El-Raouf, H., Elkholy, H., Abdul Aziz, B., Maklad, W., Turkey, A., El-sayed, H. (2018). Risk of Ischemic Heart Disease in Patients with Non-alcoholic Fatty Liver Disease. test, 8(1), 41-47. doi: 10.21608/aeji.2018.8734
Mostafa Soliman Elkady; Hatem Samir El-Raouf; Hany Ragheb Elkholy; Badawy Abdul Khalek Abdul Aziz; Wael Ahmed Maklad; Ahmed Abd El-Allah Turkey; Hayam Abd EL-Hameed El-sayed. "Risk of Ischemic Heart Disease in Patients with Non-alcoholic Fatty Liver Disease". test, 8, 1, 2018, 41-47. doi: 10.21608/aeji.2018.8734
Elkady, M., El-Raouf, H., Elkholy, H., Abdul Aziz, B., Maklad, W., Turkey, A., El-sayed, H. (2018). 'Risk of Ischemic Heart Disease in Patients with Non-alcoholic Fatty Liver Disease', test, 8(1), pp. 41-47. doi: 10.21608/aeji.2018.8734
Elkady, M., El-Raouf, H., Elkholy, H., Abdul Aziz, B., Maklad, W., Turkey, A., El-sayed, H. Risk of Ischemic Heart Disease in Patients with Non-alcoholic Fatty Liver Disease. test, 2018; 8(1): 41-47. doi: 10.21608/aeji.2018.8734

Risk of Ischemic Heart Disease in Patients with Non-alcoholic Fatty Liver Disease

Afro-Egyptian Journal of Infectious and Endemic Diseases
Article 5, Volume 8, Issue 1, March 2018, Pages 41-47    PDF (310.12 K)
Document Type: Original Article
DOI: 10.21608/aeji.2018.8734
Authors
Mostafa Soliman Elkady1; Hatem Samir El-Raouf1; Hany Ragheb Elkholy1; Badawy Abdul Khalek Abdul Aziz1; Wael Ahmed Maklad2; Ahmed Abd El-Allah Turkey3; Hayam Abd EL-Hameed El-sayed* 1
1Department of Hepatology, Gastroenterology, and Infectious Diseases,Faculty of Medicine, Benha University,Egypt
2Department of Cardiology, Benha Teaching Hospital, Benha, Egypt
3Department of Radiology, Faculty of Medicine Benha University, Benha, Egypt
Abstract
Background and study aim: Non-alcoholic fatty liver disease (NAFLD) has an increasing prevalence worldwide. It has also been closely associated with obesity and metabolic syndrome - two conditions known to be associated with ischemic heart disease (IHD). The aim of this study was to assess the association between NAFLD and ischemic heart disease.
Subjects and Methods: 140 patients with NAFLD and 70 non-NAFLD subjects were selected. Full history taking, clinical examination and laboratory tests including blood sugar, lipid profile and liver profile were done. Ultrasonography was performed to prove NAFLD while ECG and echo-cardiography were used for detection of myocardial ischemia.
Results: Of the NAFLD group, the frequency of mild, moderate and severe NAFLD was 42.9%, 30% and 27.1% respectively. Subjects with NAFLD had a significantly higher BMI, waist circumference and weight compared to those of non NAFLD group (p=0.014, 0.0218 and <0.001 respectively). Independent risk factors for NAFLD were obesity, DM, high LDL, low HDL, waist circumference,   glycated hemoglobin and IHD with odds ratios  1.09, 2.12, 1.01, 1.15, 1.13, 1.37 and 1.17 respectively. While independent risk factors for IHD included obesity, DM, high LDL, total cholesterol, triglycerides  and the presence of NAFLD with odds ratios 1.31, 1.23, 1.19, 1.132, 1.68 respectively.
Conclusion: NAFLD was independently associated with increased risk of myocardial ischemia.
Keywords
Fatty Liver; Ischemic heart disease; Metabolic syndrome
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