ABBAS, M., FAROUK, Y., HASSAN, A., HEDAYA, M., HAMDY, H., EZZAT, H., MAREI, S., ARNAOUT, H., NOSSEIR, M., ELDAMARAWY, M. (2013). PERIOPERATIVE ACUTE PHASE RESPONSE AND OUTCOME OF HEPATIC RESECTION, AN EXPERIMENTAL STUDY. test, 43(2), 341-350. doi: 10.21608/jesp.2013.94811
MOHAMED ABBAS; YOUSSEF FAROUK; AHMED ABDELAZIZ HASSAN; MOHAMED SAIED HEDAYA; HUSSAM HAMDY; HUSSEIN EZZAT; SAYED MAREI; HANAA HAMED ARNAOUT; MONA NOSSEIR; MERVAT ELDAMARAWY. "PERIOPERATIVE ACUTE PHASE RESPONSE AND OUTCOME OF HEPATIC RESECTION, AN EXPERIMENTAL STUDY". test, 43, 2, 2013, 341-350. doi: 10.21608/jesp.2013.94811
ABBAS, M., FAROUK, Y., HASSAN, A., HEDAYA, M., HAMDY, H., EZZAT, H., MAREI, S., ARNAOUT, H., NOSSEIR, M., ELDAMARAWY, M. (2013). 'PERIOPERATIVE ACUTE PHASE RESPONSE AND OUTCOME OF HEPATIC RESECTION, AN EXPERIMENTAL STUDY', test, 43(2), pp. 341-350. doi: 10.21608/jesp.2013.94811
ABBAS, M., FAROUK, Y., HASSAN, A., HEDAYA, M., HAMDY, H., EZZAT, H., MAREI, S., ARNAOUT, H., NOSSEIR, M., ELDAMARAWY, M. PERIOPERATIVE ACUTE PHASE RESPONSE AND OUTCOME OF HEPATIC RESECTION, AN EXPERIMENTAL STUDY. test, 2013; 43(2): 341-350. doi: 10.21608/jesp.2013.94811

PERIOPERATIVE ACUTE PHASE RESPONSE AND OUTCOME OF HEPATIC RESECTION, AN EXPERIMENTAL STUDY

Journal of the Egyptian Society of Parasitology
Article 6, Volume 43, Issue 2, August 2013, Pages 341-350    PDF (309.01 K)
Document Type: Original Article
DOI: 10.21608/jesp.2013.94811
Authors
MOHAMED ABBAS1; YOUSSEF FAROUK1; AHMED ABDELAZIZ HASSAN1; MOHAMED SAIED HEDAYA1; HUSSAM HAMDY1; HUSSEIN EZZAT1; SAYED MAREI2; HANAA HAMED ARNAOUT3; MONA NOSSEIR4; MERVAT ELDAMARAWY5
1Department of General Surgery, Theodor Bilharz Research Institute, Imbaba P.O.B. 30. Giza, Egypt.
2Department of General Surgery, Faculty of Medicine, Cairo University, Egypt.
3Department of Clinical Pathology, Faculty of Medicine, Cairo University, Egypt.
4Department of Pathology, Theodor Bilharz Research Institute, Imbaba P.O.B. 30. Giza, Egypt.
5Department of ICU, Theodor Bilharz Research Institute, Imbaba P.O.B. 30. Giza, Egypt.
Abstract
Identification of patients at risk of postoperative complications could have an impact on the indications for a procedure as well as permitting modifications of treatment to reduce the surgical risk. This experimental study evaluated the correlation between peri-operative acute phase response and outcome of hepatic resection. The study was conducted on sixty healthy golden hamsters, which underwent partial hepatectomy. They were arranged in 3 groups (20 per each). One day prior
to resection, fracture of the left hind leg was done in group I (G I) & wound infection had been created in group II (GII); while nothing done in group III (GIII) that acted as a control. Blood samples to estimate SGPT and serum albumin (as
basic investigations for hamsters liver function) and serum IL–6 and CRP (as acute phase reactants) were taken preoperatively, immediately after resection and for the consecutive 3 days post operatively. The mean serum level of both acute phase reactants increased in GI and GII preoperatively and continues to rise immediately after resection. Post-operatively; among the three groups, the mean serum level of both reactants was higher in GI than in GII that was in turn higher than in GIII except when the postoperative complications were more severe than the other group, then this relation changed.
Keywords
Hamster; Partial Hepatectomy; Hepatic Resection; Surgical Risk
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