Vaginal Misoprostol for Cervical Priming Before Outpatient Hysteroscopy: A Randomized Controlled Trial | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 2, Volume 72, Issue 6, July 2018, Pages 4586-4592 PDF (330.13 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2018.9785 | ||
| Authors | ||
| Anis Mansour Nagib Younis* ; Mohamed Ibrahim Amer; Malames Faisal | ||
| Department of Obstetrics and Gynecology, Faculty of Medicine, Ain shams University, Cairo, Egypt | ||
| Abstract | ||
| Background: Misoprostol has generally shown good efficacy in promoting cervical softness and facilitating hysteroscopic procedures. Objective: To evaluate the efficacy and safety of vaginal misoprostol for cervical priming before diagnostic outpatient hysteroscopy (OH) without anesthesia. Patients and Methods: Design: Double-blind randomized controlled trial. Setting: University teaching hospital. Patient(s): Ninety patients requiring diagnostic OH for investigation of infertility or abnormal uterine bleeding in the reproductive age. Intervention(s): Patients were randomly allocated into two equal groups (n= 45). In group I, 200 mcg misoprostol was inserted into the posterior vaginal fornix 3 hours before OH; in group II (control), 250 mg metronidazole as placebo was inserted into the posterior vaginal fornix by investigator. A rigid 30 4-mm hysteroscope was used in the vaginoscopic technique. Main Outcome Measure(s): Ease of cervical entry (Likert scale), procedural time, patient acceptability (Likert scale), and pain scoring (visual analog scale). Result(s): Vaginal misoprostol significantly facilitated the procedure; cervical entry was easier, procedural time was shorter, patient acceptability was higher, and pain scoring was lower in group I compared with group II. Side effects of misoprostol were infrequent, minor, and transient. No complications were reported. Conclusion(s): The regimen of 200 mcg vaginal misoprostol administered 3 hours before diagnostic OH is a simple, effective, and safe method of cervical priming to facilitate the procedure without anesthesia. | ||
| Keywords | ||
| misoprostol; cervical priming; outpatient hysteroscopy | ||
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